Xuejing Bai1, Lei Feng2. 1. Department of Laboratory, The Sixth Affiliated Hospital of Kunming Medical University, People's Hospital of Yuxi City, Yuxi, Yunnan, People's Republic of China. 2. Department of Laboratory, People's Hospital of Yuxi City, Yuxi, Yunnan, People's Republic of China.
Abstract
Background: Various biomarkers have been shown to assess and diagnose colorectal cancer in some researchers. Three indicators including PNI, SIR, GPS were used to predict the outcome for a variety of cancers in existing studies. However, few studies have analyzed the relationship between these biomarkers and different TNM staging. The aim of this study was to investigate the relationship between biomarkers and TNM staging and metastasis of CRC.Patients and methods: Three hundred fifty-five eligible patients were included who were diagnosed with CRC from October 2012 to October 2018 in People's Hospital of Yuxi City. Firstly, we separately calculated PNI, SIR markers and GPS in these patients. Next, the relationship between PNI and GPS with clinical factors were evaluated. Finally, the relationship between TNM staging and tumor metastasis was analyzed. Results: Our results demonstrate that there were statistical differences between PNI and TNM staging, distance metastasis, NLR, PLR, LMR, GPS, CEA, CA199, ALB, L, N, M, PLT, Hb, CRP. GPS with age, TNM staging, distance metastasis, NLR, CA199, ALB, N, CRP have statistical differences. PNI is associated with SIR in patients with CRC, and in which PNI is negatively proportional to NLR and PLR, but positively proportional to LMR. Conclusion: We attempt to combine PNI, SIR, GPS with TNM staging, and the results showed that the three indicators were closely related to TNM staging. Therefore, they can assist in the diagnosis of CRC and are closely related to TNM staging. Detection of three indicators is of important clinical value in the evaluation of TNM staging and metastasis prediction.
Background: Various biomarkers have been shown to assess and diagnose colorectal cancer in some researchers. Three indicators including PNI, SIR, GPS were used to predict the outcome for a variety of cancers in existing studies. However, few studies have analyzed the relationship between these biomarkers and different TNM staging. The aim of this study was to investigate the relationship between biomarkers and TNM staging and metastasis of CRC.Patients and methods: Three hundred fifty-five eligible patients were included who were diagnosed with CRC from October 2012 to October 2018 in People's Hospital of Yuxi City. Firstly, we separately calculated PNI, SIR markers and GPS in these patients. Next, the relationship between PNI and GPS with clinical factors were evaluated. Finally, the relationship between TNM staging and tumor metastasis was analyzed. Results: Our results demonstrate that there were statistical differences between PNI and TNM staging, distance metastasis, NLR, PLR, LMR, GPS, CEA, CA199, ALB, L, N, M, PLT, Hb, CRP. GPS with age, TNM staging, distance metastasis, NLR, CA199, ALB, N, CRP have statistical differences. PNI is associated with SIR in patients with CRC, and in which PNI is negatively proportional to NLR and PLR, but positively proportional to LMR. Conclusion: We attempt to combine PNI, SIR, GPS with TNM staging, and the results showed that the three indicators were closely related to TNM staging. Therefore, they can assist in the diagnosis of CRC and are closely related to TNM staging. Detection of three indicators is of important clinical value in the evaluation of TNM staging and metastasis prediction.