Delfina Janiri1,2,3, Alessio Simonetti1,3,4, Fabrizio Piras5, Valentina Ciullo5, Gianfranco Spalletta4,5, Gabriele Sani3,6,7. 1. Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy. 2. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 3. Lucio Bini Center, Rome, Italy. 4. Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. 5. IRCCS Santa Lucia Foundation, Laboratory of Neuropsychiatry, Rome, Italy. 6. NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza University of Rome, School of Medicine and Psychology, Sant'Andrea Hospital, Rome, Italy. 7. Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Abstract
OBJECTIVES: Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP. METHODS: We assessed 172 outpatients, diagnosed with BD according to DSM-IV-TR criteria, and 150 healthy control (HC) participants. High-resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer. RESULTS: Patients with depressive PP (BD-DP) and with uncertain PP (BD-UP) but not with manic/hypomanic PP (BD-MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD-DP presented with smaller bilateral presubiculum/subiculum volumes than BD-MP. CONCLUSIONS: Results support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD.
OBJECTIVES: Predominant polarity (PP) is a proposed course specifier for bipolar disorders (BD) based on patient lifetime mood episodes. Hippocampal subfield volumetric changes have been proposed as a neurobiological marker for BD and could be influenced by mood episodes. Our study aimed to test the hypothesis that patients with BD differ in hippocampal subfield volumes according to their PP. METHODS: We assessed 172 outpatients, diagnosed with BD according to DSM-IV-TR criteria, and 150 healthy control (HC) participants. High-resolution magnetic resonance imaging was performed on all subjects and volumes of all hippocampal subfields were measured using FreeSurfer. RESULTS:Patients with depressive PP (BD-DP) and with uncertain PP (BD-UP) but not with manic/hypomanic PP (BD-MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. When directly compared, BD-DP presented with smaller bilateral presubiculum/subiculum volumes than BD-MP. CONCLUSIONS: Results support the potential utility of PP not only as a clinical but also as a neurobiological specifier of BD.
Authors: Delfina Janiri; Martina Petracca; Lorenzo Moccia; Luca Tricoli; Carla Piano; Francesco Bove; Isabella Imbimbo; Alessio Simonetti; Marco Di Nicola; Gabriele Sani; Paolo Calabresi; Anna Rita Bentivoglio Journal: Front Psychiatry Date: 2020-11-27 Impact factor: 4.157
Authors: Thomas L Athey; Can Ceritoglu; Daniel J Tward; Kwame S Kutten; J Raymond DePaulo; Kara Glazer; Fernando S Goes; John R Kelsoe; Francis Mondimore; Caroline M Nievergelt; Kelly Rootes-Murdy; Peter P Zandi; J Tilak Ratnanather; Pamela B Mahon Journal: Front Psychiatry Date: 2021-02-16 Impact factor: 4.157
Authors: Philipp G Sämann; Juan Eugenio Iglesias; Boris Gutman; Dominik Grotegerd; Ramona Leenings; Claas Flint; Udo Dannlowski; Emily K Clarke-Rubright; Rajendra A Morey; Theo G M van Erp; Christopher D Whelan; Laura K M Han; Laura S van Velzen; Bo Cao; Jean C Augustinack; Paul M Thompson; Neda Jahanshad; Lianne Schmaal Journal: Hum Brain Mapp Date: 2020-12-27 Impact factor: 5.038