| Literature DB >> 31629110 |
Donghao Cai1, Ying Xu1, Rui Ding1, Kaifeng Qiu2, Ruihua Zhang1, Han Wang1, Lisi Huang1, Xiaoying Xie1, Haiyan Yan1, Yawen Deng1, Xianghua Lin1, Jing Shao3, Xiaohong Luo1, Chaohui Duan4.
Abstract
Lung cancer is a common malignant disease, nearly 2.09 million new patients occurred last year. Approximately 85% of the patients are classified as non-small-cell lung cancer (NSCLC). It is therefore important to identify new diagnostic and prognostic biomarkers for the early detection of this disease. The presented study identifies biomarkers in the serum of NSCLC patients. The expression of 274 cytokines was measured by a novel antibody array methodology and ELISA was applied to validate the array results. The levels of MIP-1 α, IL-8, MIP-1 β, Resistin, GDF-15, HGF, CA125, FLRG, VCAM-1, DKK-3, sTNF-R1, CTACK, Acrp30, CXCL-16 and LYVE-1 were significantly higher in serum from NSCLC patients, while the level of TIMP-2 and IGFBP-6 were lower. More importantly, the validation supported the result of the antibody array. The result of the antibody array indicates that these cytokines might be novel auxiliary biomarkers in the diagnosis and prognosis of NSCLC.Entities:
Keywords: Antibody array; Non-small-cell lung cancer; Serum biomarker
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Year: 2019 PMID： 31629110 DOI： 10.1016/j.cyto.2019.154868
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861