M Loef1, A Ioan-Facsinay2, D O Mook-Kanamori3, K Willems van Dijk4, R de Mutsert5, M Kloppenburg6, F R Rosendaal7. 1. Department of Rheumatology, Leiden University Medical center, the Netherlands. Electronic address: m.loef@lumc.nl. 2. Department of Rheumatology, Leiden University Medical center, the Netherlands. Electronic address: a.ioan@lumc.nl. 3. Department of Clinical Epidemiology, Leiden University Medical center, the Netherlands. Electronic address: d.o.mook@lumc.nl. 4. Department of Human Genetics, Leiden University Medical center, the Netherlands; Department of Internal Medicine, Leiden University Medical Center, the Netherlands. Electronic address: k.willems_van_dijk@lumc.nl. 5. Department of Clinical Epidemiology, Leiden University Medical center, the Netherlands. Electronic address: r.de_mutsert@lumc.nl. 6. Department of Rheumatology, Leiden University Medical center, the Netherlands; Department of Clinical Epidemiology, Leiden University Medical center, the Netherlands. Electronic address: g.kloppenburg@lumc.nl. 7. Department of Clinical Epidemiology, Leiden University Medical center, the Netherlands. Electronic address: F.R.Rosendaal@lumc.nl.
Abstract
OBJECTIVE: To investigate the association of postprandial and fasting plasma saturated fatty acid (SFAs), monounsaturated fatty acid (MUFAs) and polyunsaturated fatty acid (PUFAs) concentrations with hand and knee osteoarthritis (OA). DESIGN: In the population-based NEO study clinical hand and knee OA were defined by the ACR classification criteria. Structural knee OA was defined on MRI. Hand and knee pain was determined by Australian/Canadian Hand Osteoarthritis Index (AUSCAN) and KOOS, respectively. Plasma was sampled fasted and 150 min after a standardized meal, and subsequently analysed using a nuclear magnetic resonance platform. Logistic regression analyses were used to investigate the association of total fatty acid, SFA, MUFA, total PUFA, omega-3 PUFA and omega-6 PUFA concentrations with clinical hand and knee OA, structural knee OA and hand and knee pain. Fatty acid concentrations were standardized (mean 0, SD 1). Analyses were stratified by sex and corrected for age, education, ethnicity and total body fat percentage. RESULTS: Of the 5,328 participants (mean age 56 years, 58% women) 7% was classified with hand OA, 10% with knee OA and 4% with concurrent hand and knee OA. In men, postprandial SFAs (OR (95% CI)) 1.23 (1.00; 1.50), total PUFAs 1.26 (1.00; 1.58) and omega-3 PUFAs 1.24 (1.01; 1.52) were associated with hand OA. SFAs and PUFAs were associated with structural, but not clinical knee OA. Association of fasting fatty acid concentrations were weaker than postprandial concentrations. CONCLUSION: Plasma postprandial SFA and PUFA levels were positively associated with clinical hand and structural knee OA in men, but not in women.
OBJECTIVE: To investigate the association of postprandial and fasting plasma saturated fatty acid (SFAs), monounsaturated fatty acid (MUFAs) and polyunsaturated fatty acid (PUFAs) concentrations with hand and knee osteoarthritis (OA). DESIGN: In the population-based NEO study clinical hand and knee OA were defined by the ACR classification criteria. Structural knee OA was defined on MRI. Hand and knee pain was determined by Australian/Canadian Hand Osteoarthritis Index (AUSCAN) and KOOS, respectively. Plasma was sampled fasted and 150 min after a standardized meal, and subsequently analysed using a nuclear magnetic resonance platform. Logistic regression analyses were used to investigate the association of total fatty acid, SFA, MUFA, total PUFA, omega-3 PUFA and omega-6 PUFA concentrations with clinical hand and knee OA, structural knee OA and hand and knee pain. Fatty acid concentrations were standardized (mean 0, SD 1). Analyses were stratified by sex and corrected for age, education, ethnicity and total body fat percentage. RESULTS: Of the 5,328 participants (mean age 56 years, 58% women) 7% was classified with hand OA, 10% with knee OA and 4% with concurrent hand and knee OA. In men, postprandial SFAs (OR (95% CI)) 1.23 (1.00; 1.50), total PUFAs 1.26 (1.00; 1.58) and omega-3 PUFAs 1.24 (1.01; 1.52) were associated with hand OA. SFAs and PUFAs were associated with structural, but not clinical knee OA. Association of fasting fatty acid concentrations were weaker than postprandial concentrations. CONCLUSION: Plasma postprandial SFA and PUFA levels were positively associated with clinical hand and structural knee OA in men, but not in women.
Authors: D T Felson; D Misra; M LaValley; M Clancy; X Chen; A Lichtenstein; N Matthan; J Torner; C E Lewis; M C Nevitt Journal: Osteoarthritis Cartilage Date: 2021-03-20 Impact factor: 7.507
Authors: Anne-Mari Mustonen; Reijo Käkelä; Antti Joukainen; Petri Lehenkari; Antti Jaroma; Tommi Kääriäinen; Heikki Kröger; Tommi Paakkonen; Sanna P Sihvo; Petteri Nieminen Journal: Biology (Basel) Date: 2021-05-04