Literature DB >> 31628144

Metabolic Subtyping for Novel Personalized Therapies Against Pancreatic Cancer.

Kamiya Mehla1, Pankaj K Singh1,2,3,4.   

Abstract

Through metabolic subtyping, metabolic vulnerabilities can be exploited for developing efficacious treatments. A glycolytic subtype indicates poor survival in patients with pancreatic cancer, whereas a cholesterogenic subtype correlates with better outcomes potentially due to more energy expenditure. Personalized medicine holds great promise for improving therapy outcomes by optimally targeting metabolic pathways.See related article by Karasinska et al., p. 135. ©2019 American Association for Cancer Research.

Entities:  

Year:  2019        PMID： 31628144      PMCID： PMC6942627          DOI： 10.1158/1078-0432.CCR-19-2926

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  5 in total

1.  Altered Gene Expression along the Glycolysis-Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer.

Authors:  Joanna M Karasinska; James T Topham; Steve E Kalloger; Daniel J Renouf; David F Schaeffer; Gun Ho Jang; Robert E Denroche; Luka Culibrk; Laura M Williamson; Hui-Li Wong; Michael K C Lee; Grainne M O'Kane; Richard A Moore; Andrew J Mungall; Malcolm J Moore; Cassia Warren; Andrew Metcalfe; Faiyaz Notta; Jennifer J Knox; Steven Gallinger; Janessa Laskin; Marco A Marra; Steven J M Jones
Journal:  Clin Cancer Res       Date:  2019-09-03       Impact factor: 12.531

2.  Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial.

Authors:  Kyaw L Aung; Sandra E Fischer; Robert E Denroche; Gun-Ho Jang; Anna Dodd; Sean Creighton; Bernadette Southwood; Sheng-Ben Liang; Dianne Chadwick; Amy Zhang; Grainne M O'Kane; Hamzeh Albaba; Shari Moura; Robert C Grant; Jessica K Miller; Faridah Mbabaali; Danielle Pasternack; Ilinca M Lungu; John M S Bartlett; Sangeet Ghai; Mathieu Lemire; Spring Holter; Ashton A Connor; Richard A Moffitt; Jen Jen Yeh; Lee Timms; Paul M Krzyzanowski; Neesha Dhani; David Hedley; Faiyaz Notta; Julie M Wilson; Malcolm J Moore; Steven Gallinger; Jennifer J Knox
Journal:  Clin Cancer Res       Date:  2017-12-29       Impact factor: 12.531

3.  De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer.

Authors:  Saber Tadros; Surendra K Shukla; Ryan J King; Venugopal Gunda; Enza Vernucci; Jaime Abrego; Nina V Chaika; Fang Yu; Audrey J Lazenby; Lyudmyla Berim; Jean Grem; Aaron R Sasson; Pankaj K Singh
Journal:  Cancer Res       Date:  2017-08-15       Impact factor: 13.312

4.  Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma.

Authors:  Nina V Chaika; Fang Yu; Vinee Purohit; Kamiya Mehla; Audrey J Lazenby; Dominick DiMaio; Judy M Anderson; Jen Jen Yeh; Keith R Johnson; Michael A Hollingsworth; Pankaj K Singh
Journal:  PLoS One       Date:  2012-03-07       Impact factor: 3.240

5.  MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.

Authors:  Surendra K Shukla; Vinee Purohit; Kamiya Mehla; Venugopal Gunda; Nina V Chaika; Enza Vernucci; Ryan J King; Jaime Abrego; Gennifer D Goode; Aneesha Dasgupta; Alysha L Illies; Teklab Gebregiworgis; Bingbing Dai; Jithesh J Augustine; Divya Murthy; Kuldeep S Attri; Oksana Mashadova; Paul M Grandgenett; Robert Powers; Quan P Ly; Audrey J Lazenby; Jean L Grem; Fang Yu; José M Matés; John M Asara; Jung-Whan Kim; Jordan H Hankins; Colin Weekes; Michael A Hollingsworth; Natalie J Serkova; Aaron R Sasson; Jason B Fleming; Jennifer M Oliveto; Costas A Lyssiotis; Lewis C Cantley; Lyudmyla Berim; Pankaj K Singh
Journal:  Cancer Cell       Date:  2017-07-10       Impact factor: 38.585
  5 in total
  5 in total

1.  Exploring the metabolic landscape of pancreatic ductal adenocarcinoma cells using genome-scale metabolic modeling.

Authors:  Mohammad Mazharul Islam; Andrea Goertzen; Pankaj K Singh; Rajib Saha
Journal:  iScience       Date:  2022-05-30

Review 2.  The interactive role of inflammatory mediators and metabolic reprogramming in pancreatic cancer.

Authors:  Yuuki Ohara; Paloma Valenzuela; S Perwez Hussain
Journal:  Trends Cancer       Date:  2022-05-05

3.  Molecular Subtypes of Pancreatic Cancer: A Proteomics Approach.

Authors:  Ravi Thakur; Pankaj K Singh
Journal:  Clin Cancer Res       Date:  2021-04-14       Impact factor: 12.531

Review 4.  Metabolism of pancreatic cancer: paving the way to better anticancer strategies.

Authors:  Cheng Qin; Gang Yang; Jinshou Yang; Bo Ren; Huanyu Wang; Guangyu Chen; Fangyu Zhao; Lei You; Weibin Wang; Yupei Zhao
Journal:  Mol Cancer       Date:  2020-03-02       Impact factor: 27.401

5.  A cholesterogenic gene signature for predicting the prognosis of young breast cancer patients.

Authors:  Xiaoping Li; Chaorong Zhou; Chaoran Qiu; Weiwen Li; Qihe Yu; Hui Huang; Yiwen Zhang; Xin Zhang; Liangliang Ren; Xin Huang; Qinghua Zhou
Journal:  PeerJ       Date:  2022-08-18       Impact factor: 3.061
  5 in total

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