| Literature DB >> 31626911 |
Yan Chen1, Wencong Yang2, Ge Zou2, Shenyu Chen2, Jiyan Pang2, Zhigang She3.
Abstract
Five new polyketides, colletotric B (2), 3-hydroxy-5-methoxy-2,4,6-trimethylbenzoic acid (3), colletotric C (4), chaetochromone D (6) and 8-hydroxy-pregaliellalactone B (9), together with four known analogues (1, 5 and 7-8) were isolated from the mangrove endophytic fungus Phoma sp. SYSU-SK-7. Their structures were elucidated by analysis of extensive spectroscopic data and mass spectrometric data. Compounds 1-2 showed strong antimicrobial activity against the P. aeruginosa, MRSA and C. albicans with the MIC values in the range of 1.67-6.28 μg/ml. Furthermore, Compounds 1-5 also exhibited significant α-glucosidase inhibitory activity with the IC50 values in the range of 36.2-90.6 μM. Compound 7 was found to inhibited radical scavenging activity against DPPH with the EC50 value of 11.8 μM.Entities:
Keywords: Antimicrobial activity; DPPH scavenging activity; Phoma sp.; Polyketides; α-glucosidase inhibitory activity
Year: 2019 PMID： 31626911 DOI： 10.1016/j.fitote.2019.104369
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882