Literature DB >> 3162654

Pharmacokinetics and tissue kinetics of 1 gm cefotetan prophylaxis in abdominal or vaginal hysterectomy.

J W Orr1, P F Sisson, J M Barrett, J R Ellington, R H Jennings, D L Taylor.   

Abstract

Plasma and tissue levels of cefotetan after a single-gram intravenous preoperative dose were measured. Levels were high in some tissues (parametrium, fascia) but quite low in others (subcutaneous fat). The implications as to the prophylactic effectiveness of this drug are addressed.

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Year:  1988        PMID: 3162654     DOI: 10.1016/s0002-9378(16)44538-2

Source DB:  PubMed          Journal:  Am J Obstet Gynecol        ISSN: 0002-9378            Impact factor:   8.661


  3 in total

1.  Anti-anaerobic antimicrobial agents: cefoxitin, cefotetan, clindamycin, and metronidazole.

Authors:  J A Bosso; R A Prince
Journal:  Tex Heart Inst J       Date:  1990

Review 2.  Antibiotic prophylaxis in hysterectomy and induced abortion. A review of the evidence.

Authors:  E T Houang
Journal:  Drugs       Date:  1991-01       Impact factor: 9.546

Review 3.  Clinical pharmacokinetics of cefotetan.

Authors:  C Martin; L Thomachot; J Albanese
Journal:  Clin Pharmacokinet       Date:  1994-04       Impact factor: 6.447

  3 in total

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