| Literature DB >> 31626249 |
Matthew Worth1, Chia-Wei Hu2, Hao Li2, Dacheng Fan2, Arielis Estevez2, Dongsheng Zhu2, Ao Wang2, Jiaoyang Jiang2.
Abstract
O-GlcNAc transferase (OGT) glycosylates numerous proteins and is implicated in many diseases. To date, most OGT inhibitors lack either sufficient potency or characterized specificity in cells. We report the first targeted covalent inhibitor that predominantly reacts with OGT but does not affect other functionally similar enzymes. This study provides a new strategy to interrogate cellular OGT functions and to investigate other glycosyltransferases.Entities:
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Year: 2019 PMID： 31626249 PMCID： PMC6823131 DOI： 10.1039/c9cc04560k
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222