Vladimir Egorov1, Peter Takacs2, S Abbas Shobeiri3, Lennox Hoyte4, Vincent Lucente5, Heather van Raalte6, Noune Sarvazyan1. 1. From the Artann Laboratories, Trenton, NJ. 2. Eastern Virginia Medical School, Norfolk, VA. 3. INOVA Fairfax Hospital, Falls Church. 4. The Pelvic Floor Institute, Tampa, FL. 5. The Institute for Female Pelvic Medicine and Reconstructive Surgery, Allentown, PA. 6. Princeton Urogynecology, Princeton, NJ.
Abstract
OBJECTIVE: This study examined biomechanical changes in pelvic floor after urogynecological surgery. METHODS: This multisite clinical study was designed to explore changes in tissue elasticity, pelvic support, and certain functions (contractive strength, muscle relaxation speed, muscle motility) after pelvic organ prolapse (POP) surgery. A biomechanical mapping of the pelvic floor was performed before and 4 to 6 months after the surgery. The biomechanical data for 52 parameters were acquired by vaginal tactile imaging for manually applied deflection pressures to vaginal walls and pelvic muscle contractions. The two-sample t-test (P < 0.05) was used to test the null hypothesis that presurgery data in group 1 (positive parameter change after surgery) and presurgery data in group 2 (negative parameter change after surgery) belonged to the same distribution. RESULTS: A total of 78 subjects with 255 surgical procedures were analyzed across 5 participating clinical sites. All 52 t-tests for group 1 versus group 2 had P value in the range from 4.0 × 10-10 to 4.3 × 10-2 associating all of the 52 parameter changes after surgery with the presurgical conditions. The P value of before and after surgery correlation ranged from 3.7 × 10-18 to 1.6 × 10-2 for 50 of 52 tests, with Pearson correlation coefficient ranging from -0.79 to -0.27. Thus, vaginal tactile imaging parameters strongly correlated weak pelvic floor presurgery with the positive POP surgery outcome of improved biomechanical properties. CONCLUSIONS: Pelvic organ prolapse surgery, in general, improves the biomechanical conditions and integrity of the weak pelvic floor. The proposed biomechanical parameters can predict changes resulting from POP surgery.
OBJECTIVE: This study examined biomechanical changes in pelvic floor after urogynecological surgery. METHODS: This multisite clinical study was designed to explore changes in tissue elasticity, pelvic support, and certain functions (contractive strength, muscle relaxation speed, muscle motility) after pelvic organ prolapse (POP) surgery. A biomechanical mapping of the pelvic floor was performed before and 4 to 6 months after the surgery. The biomechanical data for 52 parameters were acquired by vaginal tactile imaging for manually applied deflection pressures to vaginal walls and pelvic muscle contractions. The two-sample t-test (P < 0.05) was used to test the null hypothesis that presurgery data in group 1 (positive parameter change after surgery) and presurgery data in group 2 (negative parameter change after surgery) belonged to the same distribution. RESULTS: A total of 78 subjects with 255 surgical procedures were analyzed across 5 participating clinical sites. All 52 t-tests for group 1 versus group 2 had P value in the range from 4.0 × 10-10 to 4.3 × 10-2 associating all of the 52 parameter changes after surgery with the presurgical conditions. The P value of before and after surgery correlation ranged from 3.7 × 10-18 to 1.6 × 10-2 for 50 of 52 tests, with Pearson correlation coefficient ranging from -0.79 to -0.27. Thus, vaginal tactile imaging parameters strongly correlated weak pelvic floor presurgery with the positive POP surgery outcome of improved biomechanical properties. CONCLUSIONS: Pelvic organ prolapse surgery, in general, improves the biomechanical conditions and integrity of the weak pelvic floor. The proposed biomechanical parameters can predict changes resulting from POP surgery.
Authors: R C Bump; A Mattiasson; K Bø; L P Brubaker; J O DeLancey; P Klarskov; B L Shull; A R Smith Journal: Am J Obstet Gynecol Date: 1996-07 Impact factor: 8.661
Authors: Vladimir Egorov; Vincent Lucente; Heather VAN Raalte; Miles Murphy; Sonya Ephrain; Nina Bhatia; Noune Sarvazyan Journal: Pelviperineology Date: 2019-03
Authors: J Eric Jelovsek; Matthew D Barber; Linda Brubaker; Peggy Norton; Marie Gantz; Holly E Richter; Alison Weidner; Shawn Menefee; Joseph Schaffer; Norma Pugh; Susan Meikle Journal: JAMA Date: 2018-04-17 Impact factor: 56.272
Authors: Vladimir Egorov; Miles Murphy; Vincent Lucente; Heather van Raalte; Sonya Ephrain; Nina Bhatia; Noune Sarvazyan Journal: Sex Med Date: 2017-12-19 Impact factor: 2.491
Authors: Vladimir Egorov; S Abbas Shobeiri; Peter Takacs; Lennox Hoyte; Vincent Lucente; Heather van Raalte Journal: Open J Obstet Gynecol Date: 2018-08-31