Nozomu Uchida1,2, Kyoko Ishida3, Ayako Anraku2, Asuka Takeyama2,4, Goji Tomita2. 1. Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo, Japan. 2. Department of Ophthalmology, Toho University Ohashi Medical Center, 2-22-36 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan. 3. Department of Ophthalmology, Toho University Ohashi Medical Center, 2-22-36 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan. kyoko.ish@gmail.com. 4. Department of Ophthalmology, Teikyo University School of Medicine, University Hospital Mizonokuchi, Kawasaki, Japan.
Abstract
PURPOSE: To investigate macular vessel density (MVD) and structural alterations in untreated normal tension glaucoma (NTG) with a hemifield defect (HFD) and to compare these with the findings in healthy eyes. STUDY DESIGN: Case series with a healthy group for comparison. METHODS: Thirty-four eyes of 34 untreated NTG patients with HFD and 28 eyes of 28 healthy subjects were enrolled. RTVue-XR AvantiTM (Optovue, Inc.), a combined OCT-A and SD-OCT system, was used to determine MVD and inner macular thickness (IMT) measurements. Mean circumpapillary retinal nerve fiber (cpRNFL) and macular ganglion cell complex (mGCC) thicknesses were measured with the RTVue-100TM (Optovue, Inc.). Wilcoxon signed-rank test was used to evaluate differences between defective and normal hemifields in NTG eyes and Mann-Whitney U test to evaluate differences between normal hemifields in NTG eyes and healthy eyes. RESULTS: In comparison with healthy eyes, the normal hemifields of NTG eyes showed significantly reduced MVD, as well as cpRNFL and mGCC thicknesses, although IMT did not differ between the two groups. The defective hemifield in NTG eyes showed significantly reduced IMT, as well as cpRNFL and mGCC thicknesses, compared with the normal hemifield, although MVD did not differ between the two hemifields. CONCLUSION: Hemodynamic deficiencies and structural damage might have already begun in the perimetrically normal hemifields of NTG eyes. Further studies are needed to elucidate whether the reduction in MVD may precede structural changes or the reduction in vasculature and structural loss may vary with disease severity in at least in some cases.
PURPOSE: To investigate macular vessel density (MVD) and structural alterations in untreated normal tension glaucoma (NTG) with a hemifield defect (HFD) and to compare these with the findings in healthy eyes. STUDY DESIGN: Case series with a healthy group for comparison. METHODS: Thirty-four eyes of 34 untreated NTG patients with HFD and 28 eyes of 28 healthy subjects were enrolled. RTVue-XR AvantiTM (Optovue, Inc.), a combined OCT-A and SD-OCT system, was used to determine MVD and inner macular thickness (IMT) measurements. Mean circumpapillary retinal nerve fiber (cpRNFL) and macular ganglion cell complex (mGCC) thicknesses were measured with the RTVue-100TM (Optovue, Inc.). Wilcoxon signed-rank test was used to evaluate differences between defective and normal hemifields in NTG eyes and Mann-Whitney U test to evaluate differences between normal hemifields in NTG eyes and healthy eyes. RESULTS: In comparison with healthy eyes, the normal hemifields of NTG eyes showed significantly reduced MVD, as well as cpRNFL and mGCC thicknesses, although IMT did not differ between the two groups. The defective hemifield in NTG eyes showed significantly reduced IMT, as well as cpRNFL and mGCC thicknesses, compared with the normal hemifield, although MVD did not differ between the two hemifields. CONCLUSION: Hemodynamic deficiencies and structural damage might have already begun in the perimetrically normal hemifields of NTG eyes. Further studies are needed to elucidate whether the reduction in MVD may precede structural changes or the reduction in vasculature and structural loss may vary with disease severity in at least in some cases.
Authors: Huiyuan Hou; Sasan Moghimi; Linda M Zangwill; Takuhei Shoji; Elham Ghahari; Rafaella C Penteado; Tadamichi Akagi; Patricia Isabel C Manalastas; Robert N Weinreb Journal: Am J Ophthalmol Date: 2018-11-26 Impact factor: 5.258
Authors: Sasan Moghimi; Linda M Zangwill; Rafaella C Penteado; Kyle Hasenstab; Elham Ghahari; Huiyuan Hou; Mark Christopher; Adeleh Yarmohammadi; Patricia Isabel C Manalastas; Takuhei Shoji; Christopher Bowd; Robert N Weinreb Journal: Ophthalmology Date: 2018-06-12 Impact factor: 12.079
Authors: Huiyuan Hou; Sasan Moghimi; Linda M Zangwill; Takuhei Shoji; Elham Ghahari; Patricia Isabel C Manalastas; Rafaella C Penteado; Robert N Weinreb Journal: Am J Ophthalmol Date: 2018-03-24 Impact factor: 5.258
Authors: Hana L Takusagawa; Liang Liu; Kelly N Ma; Yali Jia; Simon S Gao; Miao Zhang; Beth Edmunds; Mansi Parikh; Shandiz Tehrani; John C Morrison; David Huang Journal: Ophthalmology Date: 2017-07-01 Impact factor: 12.079