| Literature DB >> 31623952 |
Abstract
Malaria vaccines targeting merozoite invasion of erythrocytes have long held appeal but failed in clinical trials. Three structural studies of antibody-antigen complexes by Alanine et al., Urusova et al., and Rawlinson et al. define neutralizing and nonneutralizing epitopes in essential invasion proteins, leading to rational design of improved merozoite vaccines. Published by Elsevier Ltd.Entities:
Keywords: Plasmodium falciparum; Plasmodium vivax; X-ray crystallography; epitopes; malaria vaccine; neutralizing antibody
Year: 2019 PMID： 31623952 DOI： 10.1016/j.pt.2019.09.004
Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922