| Literature DB >> 31623932 |
Hanlin Zeng1, Robert L Judson-Torres1, A Hunter Shain2.
Abstract
To date, over 1000 melanocytic neoplasms, spanning all stages of tumorigenesis, have been sequenced, offering detailed views into their -omic landscapes. This has coincided with advances in genetic engineering technologies that allow molecular biologists to edit the human genome with extreme precision and new mouse models to simulate disease progression. In this review, we describe how these technologies are being harnessed to provide insights into the evolution of melanoma at an unprecedented resolution, revealing that prior models of melanoma evolution, in which pathways are turned 'on' or 'off' in a binary fashion during the run-up to melanoma, are oversimplified.Entities:
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Year: 2019 PMID： 31623932 PMCID： PMC6983335 DOI： 10.1016/j.jid.2019.08.002
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551