| Literature DB >> 31623928 |
Mara De Martino1, Claire Vanpouille-Box2.
Abstract
In a recent study in Oncoimmunology, Rodriguez-Ruiz et al. demonstrate that the apoptotic executioner caspase 3 (CASP3) attenuates antitumor immune responses induced by radiation therapy (RT) by inhibiting the release of cytosolic DNA. CASP3 stands out as a promising target for the development of novel strategies to improve anticancer responses driven by RT.Entities:
Keywords: CASP3; CGAS; SLC7A2; immune checkpoint blockers; mitochondrial outer membrane permeabilization; radiation therapy
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Year: 2019 PMID： 31623928 DOI： 10.1016/j.tcb.2019.09.001
Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808