Literature DB >> 31623867

Microglial Self-Recognition STINGs in A-T Neurodegeneration.

Austin Ferro1, Carrie Sheeler1, Marija Cvetanovic2.   

Abstract

Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ATM; NF-κB; ataxia telangiectasia; microglia

Mesh：

Substances：

Year:  2019        PMID： 31623867      PMCID： PMC7178899          DOI： 10.1016/j.tins.2019.09.005

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  10 in total

1.  An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.

Authors:  Ye Zhang; Kenian Chen; Steven A Sloan; Mariko L Bennett; Anja R Scholze; Sean O'Keeffe; Hemali P Phatnani; Paolo Guarnieri; Christine Caneda; Nadine Ruderisch; Shuyun Deng; Shane A Liddelow; Chaolin Zhang; Richard Daneman; Tom Maniatis; Ben A Barres; Jian Qian Wu
Journal:  J Neurosci       Date:  2014-09-03       Impact factor: 6.167

2.  Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.

Authors:  Hazel Quek; John Luff; KaGeen Cheung; Sergei Kozlov; Magtouf Gatei; C Soon Lee; Mark C Bellingham; Peter G Noakes; Yi Chieh Lim; Nigel L Barnett; Steven Dingwall; Ernst Wolvetang; Tomoji Mashimo; Tara L Roberts; Martin F Lavin
Journal:  J Leukoc Biol       Date:  2016-11-28       Impact factor: 4.962

3.  Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences.

Authors:  Xuan Song; Fulin Ma; Karl Herrup
Journal:  J Neurosci       Date:  2019-06-12       Impact factor: 6.167

4.  Non-self mutation: double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases.

Authors:  Clare L van Eyk; Saumya E Samaraweera; Andrew Scott; Dani L Webber; David P Harvey; Olivia Mecinger; Louise V O'Keefe; Jennifer E Cropley; Paul Young; Joshua Ho; Catherine Suter; Robert I Richards
Journal:  Hum Mol Genet       Date:  2019-09-15       Impact factor: 6.150

5.  ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila.

Authors:  Andrew J Petersen; Stacey A Rimkus; David A Wassarman
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-21       Impact factor: 11.205

6.  Individual Cytokines Modulate the Neurological Symptoms of ATM Deficiency in a Region Specific Manner

Authors:  Chin Wai Hui; Karl Herrup
Journal:  eNeuro       Date:  2015-08-18

7.  Microglial brain region-dependent diversity and selective regional sensitivities to aging.

Authors:  Kathleen Grabert; Tom Michoel; Michail H Karavolos; Sara Clohisey; J Kenneth Baillie; Mark P Stevens; Tom C Freeman; Kim M Summers; Barry W McColl
Journal:  Nat Neurosci       Date:  2016-01-18       Impact factor: 24.884

8.  Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice.

Authors:  Chin Wai Hui; Xuan Song; Fulin Ma; Xuting Shen; Karl Herrup
Journal:  J Neuroinflammation       Date:  2018-11-06       Impact factor: 8.322

9.  Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.

Authors:  Rui Gao; Anirban Chakraborty; Charlene Geater; Subrata Pradhan; Kara L Gordon; Jeffrey Snowden; Subo Yuan; Audrey S Dickey; Sanjeev Choudhary; Tetsuo Ashizawa; Lisa M Ellerby; Albert R La Spada; Leslie M Thompson; Tapas K Hazra; Partha S Sarkar
Journal:  Elife       Date:  2019-04-17       Impact factor: 8.140

10.  Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells.

Authors:  Thomas P Chapman; Daniele Corridoni; Seiji Shiraishi; Sumeet Pandey; Anna Aulicino; Simon Wigfield; Maria do Carmo Costa; Marie-Laëtitia Thézénas; Henry Paulson; Roman Fischer; Benedikt M Kessler; Alison Simmons
Journal:  Front Immunol       Date:  2019-07-19       Impact factor: 7.561
  10 in total
  2 in total

1.  DNA Repair Inhibition Leads to Active Export of Repetitive Sequences to the Cytoplasm Triggering an Inflammatory Response.

Authors:  Xuan Song; Jacqueline T M Aw; Fulin Ma; Ming Fung Cheung; Danny Leung; Karl Herrup
Journal:  J Neurosci       Date:  2021-09-30       Impact factor: 6.167

Review 2.  Translational pediatrics: clinical perspective for Phelan-McDermid syndrome and autism research.

Authors:  Yasunari Sakai; Sayaka Okuzono; Christian P Schaaf; Shouichi Ohga
Journal:  Pediatr Res       Date:  2021-10-26       Impact factor: 3.953
  2 in total

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