Literature DB >> 31622747

Regulating membrane lipid levels at the synapse by small-molecule inhibitors of monoacylglycerol lipase: new developments in therapeutic and PET imaging applications.

Natasha L Grimsey1, Juha R Savinainen2, Bala Attili3, Muneer Ahamed4.   

Abstract

Monoacylglycerol lipase (MAGL) is a major endocannabinoid hydrolyzing enzyme and can be regulated to control endogenous lipid levels in the brain. This review highlights the pharmacological roles and in vivo PET imaging of MAGL in brain.
Copyright © 2019 Elsevier Ltd. All rights reserved.

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Year:  2019        PMID： 31622747     DOI： 10.1016/j.drudis.2019.10.004

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  6 in total

1.  A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network.

Authors:  Ran Cheng; Masayuki Fujinaga; Jing Yang; Jian Rong; Ahmed Haider; Daisuke Ogasawara; Richard S Van; Tuo Shao; Zhen Chen; Xiaofei Zhang; Erick R Calderon Leon; Yiding Zhang; Wakana Mori; Katsushi Kumata; Tomoteru Yamasaki; Lin Xie; Shaofa Sun; Lu Wang; Chongzhao Ran; Yihan Shao; Benjamin Cravatt; Lee Josephson; Ming-Rong Zhang; Steven H Liang
Journal:  Acta Pharmacol Sin       Date:  2022-05-05       Impact factor: 6.150

2.  Novel Oxazine Monoacylglycerol Lipase (MAGL) Inhibitors.

Authors:  Ram W Sabnis
Journal:  ACS Med Chem Lett       Date:  2021-02-04       Impact factor: 4.345

3.  Heterocyclic Compounds as Monoacylglycerol Lipase (MAGL) Inhibitors.

Authors:  Ram W Sabnis
Journal:  ACS Med Chem Lett       Date:  2021-03-31       Impact factor: 4.345

4.  Classics in Neuroimaging: Imaging the Endocannabinoid Pathway with PET.

Authors:  Cassis Varlow; Isabelle Boileau; Hsiao-Ying Wey; Steven H Liang; Neil Vasdev
Journal:  ACS Chem Neurosci       Date:  2020-06-19       Impact factor: 5.780

5.  Comparative Analysis of the Transcriptome and Distribution of Putative SNPs in Two Rainbow Trout (Oncorhynchus mykiss) Breeding Strains by Using Next-Generation Sequencing.

Authors:  Lidia de Los Ríos-Pérez; Ronald Marco Brunner; Frieder Hadlich; Alexander Rebl; Carsten Kühn; Dörte Wittenburg; Tom Goldammer; Marieke Verleih
Journal:  Genes (Basel)       Date:  2020-07-24       Impact factor: 4.096

6.  Target occupancy study and whole-body dosimetry with a MAGL PET ligand [11C]PF-06809247 in non-human primates.

Authors:  Ryosuke Arakawa; Akihiro Takano; Sangram Nag; Zhisheng Jia; Nahid Amini; Kevin P Maresca; Lei Zhang; Edmund J Keliher; Christopher R Butler; Justin R Piro; Tarek A Samad; Deborah Smith; Deane Nason; Steve O'Neil; Patrick Trapa; Kari R Fonseca; John Litchfield; Timothy McCarthy; Richard E Carson; Christer Halldin
Journal:  EJNMMI Res       Date:  2022-03-04       Impact factor: 3.138
  6 in total

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