Ryul Kim1, Dallah Yoo2, Ji-Hyun Choi1, Jung Hwan Shin1, Sangmin Park1, Han-Joon Kim1, Sun Ha Paek3, Beomseok Jeon4. 1. Department of Neurology, College of Medicine, Seoul National University Hospital, Seoul, South Korea. 2. Department of Neurology, Kyung Hee University Medical Center, Seoul, South Korea. 3. Department of Neurosurgery, College of Medicine, Seoul National University Hospital, Seoul, South Korea. Electronic address: paeksh@snu.ac.kr. 4. Department of Neurology, College of Medicine, Seoul National University Hospital, Seoul, South Korea. Electronic address: brain@snu.ac.kr.
Abstract
OBJECTIVE: To assess the influence of sex on the short-term and long-term effects of subthalamic nucleus stimulation (STN-DBS) in Parkinson's disease (PD) METHODS: We evaluated 48 male and 52 female PD patients enrolled in our prospective DBS registry who received bilateral STN-DBS between 2005 and 2013 and had 5-year follow-up data. Motor function, dyskinesia duration/disability, activities of daily living, health-related quality of life (HRQoL), cognitive function, and depression severity were investigated at baseline and at the 1- and 5-year follow-up visits. HRQoL was assessed using the 36-Item Short Form Health Survey (SF-36), which consists of physical-component summary (PCS) and mental-component summary scores. RESULTS: None of the changes from baseline to the 1- or 5-year follow-up in clinical outcomes differed between the men and women except for the SF-36 PCS scores. Compared with the baseline, there was an improvement in the PCS scores in both men (p < 0.001) and women (p = 0.001) at the 1-year follow-up; however, a trend toward greater improvement in men was observed (p = 0.061). At the 5-year follow-up, STN-DBS improved the PCS scores in men (p < 0.001) but not in women (p=0.409) compared with the baseline, and there was a significant difference between the groups (p = 0.002). CONCLUSIONS: Our data suggest that STN-DBS induce a similar degree of short-term and long-term effects on motor function, cognitive and depressive symptoms, and functional status between male and female PD patients. Nevertheless, physical HRQoL seemed to improve to a greater extent in men, and this sex difference was more prominent with long-term observation.
OBJECTIVE: To assess the influence of sex on the short-term and long-term effects of subthalamic nucleus stimulation (STN-DBS) in Parkinson's disease (PD) METHODS: We evaluated 48 male and 52 female PDpatients enrolled in our prospective DBS registry who received bilateral STN-DBS between 2005 and 2013 and had 5-year follow-up data. Motor function, dyskinesia duration/disability, activities of daily living, health-related quality of life (HRQoL), cognitive function, and depression severity were investigated at baseline and at the 1- and 5-year follow-up visits. HRQoL was assessed using the 36-Item Short Form Health Survey (SF-36), which consists of physical-component summary (PCS) and mental-component summary scores. RESULTS: None of the changes from baseline to the 1- or 5-year follow-up in clinical outcomes differed between the men and women except for the SF-36 PCS scores. Compared with the baseline, there was an improvement in the PCS scores in both men (p < 0.001) and women (p = 0.001) at the 1-year follow-up; however, a trend toward greater improvement in men was observed (p = 0.061). At the 5-year follow-up, STN-DBS improved the PCS scores in men (p < 0.001) but not in women (p=0.409) compared with the baseline, and there was a significant difference between the groups (p = 0.002). CONCLUSIONS: Our data suggest that STN-DBS induce a similar degree of short-term and long-term effects on motor function, cognitive and depressive symptoms, and functional status between male and female PDpatients. Nevertheless, physical HRQoL seemed to improve to a greater extent in men, and this sex difference was more prominent with long-term observation.
Authors: Stefanie T Jost; Lena Strobel; Alexandra Rizos; Philipp A Loehrer; Keyoumars Ashkan; Julian Evans; Franz Rosenkranz; Michael T Barbe; Gereon R Fink; Jeremy Franklin; Anna Sauerbier; Christopher Nimsky; Afsar Sattari; K Ray Chaudhuri; Angelo Antonini; Lars Timmermann; Pablo Martinez-Martin; Monty Silverdale; Elke Kalbe; Veerle Visser-Vandewalle; Haidar S Dafsari Journal: NPJ Parkinsons Dis Date: 2022-04-20