| Literature DB >> 31621316 |
Yongpeng Yao1, Chunyan An1, Declan Evans2, Weiwei Liu1, Wei Wang1,3, Guangzheng Wei1,3, Ning Ding4, K N Houk2, Shu-Shan Gao1.
Abstract
A dedicated enzyme for the formation of the central C ring in the tetracyclic ergoline of clinically important ergot alkaloids has never been found. Herein, we report a dual role catalase (EasC), unexpectedly using O2 as the oxidant, that catalyzes the oxidative cyclization of the central C ring from a 1,3-diene intermediate. Our study showcases how nature evolves the common catalase for enantioselective C-C bond construction of complex polycyclic scaffolds.Entities:
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Year: 2019 PMID： 31621316 PMCID： PMC7592905 DOI： 10.1021/jacs.9b10217
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419