| Literature DB >> 31621076 |
Jian Fang1, Xuhui Ge2, Wenjing Xu2, Jingjing Xie2, Zhongke Qin2, Liqing Shi2, Wenjie Yin2, Maohong Bian1, Hao Wang2.
Abstract
High mobility group box (HMGB) consists primarily of HMGB1, HMGB2, and HMGB3 proteins. Although abnormal HMGB expression is associated with various tumors, the relationship with gastric cancer (GC) remains unclear. In this study, HMGB1, HMGB2, and HMGB3 expression was analyzed using the Oncomine and TCGA databases. Correlations between HMGB1, HMGB2, and HMGB3 and clinicopathological factors were analyzed. cBioPortal was used to analyze HMGB1, HMGB2, and HMGB3 genetic alterations and its gene regulation network in GC tissue. HMGB1, HMGB2, and HMGB3 expression was higher in tumor tissues than in normal tissues, especially in GC. High HMGB1, HMGB2, and HMGB3 expression may predict a poor prognosis among patients with GC (hazard ratios [HR] = 1.90; 95% confidence interval [CI]: [1.30-2.78]) and human digestive system neoplasm (HR = 1.85; 95% CI [1.64-2.10]). These findings suggest that HMGB1, HMGB2, and HMGB3 may be useful prognostic indicators for patients with GC.Entities:
Keywords: gastric cancer; high mobility group boxes; prognosis
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Year: 2019 PMID： 31621076 DOI： 10.1002/jcp.29233
Source DB: PubMed Journal: J Cell Physiol ISSN： 0021-9541 Impact factor: 6.384