Gavin Hudson1, Yuko Takeda2, Mary Herbert3,4. 1. Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. gavin.hudson@newcastle.ac.uk. 2. Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. 3. Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. mary.herbert@newcastle.ac.uk. 4. Newcastle Fertility Centre, Newcastle upon Tyne, UK. mary.herbert@newcastle.ac.uk.