Caihong Xin1, Xin Sun2,3, Li Lu4, Rong Yang4, Ling Shan4, Yang Wang4. 1. Department of Endocrinology and Metabolism, The Fourth People's Hospital of Shenyang, Shenyang, China. 2. Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou, China, sunxin77@126.com. 3. Department of Endocrinology and Metabolism, The People's Hospital of China Medical University, Shenyang, China, sunxin77@126.com. 4. Department of Endocrinology and Metabolism, The People's Hospital of China Medical University, Shenyang, China.
Abstract
BACKGROUND: Alopecia areata (AA) is a common, clinically heterogeneous, immune-mediated, nonscarring hair loss disease with a pathogenesis that is not fully understood. The prevalence of thyroid disease is likely increased among individuals with AA. However, this association remains controversial. OBJECTIVE: To evaluate the risk of thyroid disease in patients with AA. METHODS: We performed a systematic review by searching both English and Chinese literature databases. Random- or fixed-effects models were used to summarize the association between thyroid disease and AA. RESULTS: In total, 17 articles were included in this meta-analysis, with 2,850 AA cases and 4,667 controls. Overall, the prevalence of thyroid disease in patients with AA was significantly increased compared with that in controls (odds ratios 3.66, 95% confidence intervals 2.90-4.61). CONCLUSIONS: The results suggest that AA patients should be screened for thyroid disease.
BACKGROUND:Alopecia areata (AA) is a common, clinically heterogeneous, immune-mediated, nonscarring hair loss disease with a pathogenesis that is not fully understood. The prevalence of thyroid disease is likely increased among individuals with AA. However, this association remains controversial. OBJECTIVE: To evaluate the risk of thyroid disease in patients with AA. METHODS: We performed a systematic review by searching both English and Chinese literature databases. Random- or fixed-effects models were used to summarize the association between thyroid disease and AA. RESULTS: In total, 17 articles were included in this meta-analysis, with 2,850 AA cases and 4,667 controls. Overall, the prevalence of thyroid disease in patients with AA was significantly increased compared with that in controls (odds ratios 3.66, 95% confidence intervals 2.90-4.61). CONCLUSIONS: The results suggest that AApatients should be screened for thyroid disease.