Literature DB >> 316187

Cigarette smoke inhalation decreases alpha 1-antitrypsin activity in rat lung.

A Janoff, H Carp, D K Lee, R T Drew.   

Abstract

Brief inhalation exposure of rats to three or six puffs of cigarette smoke significantly decreases elastase inhibitory capacity per milligram of alpha 1-antitrypsin in lung lavage fluid. This effect is not observed in ozone-tolerant rats and can be reversed by treating the lung lavage fluid from smoke-exposed rats with reducing agents. Samples of human serum obtained immediately after smoking also show decreased elastase inhibitory capacity per milligram of alpha 1-antitrypsin. Again, elastase inhibitory capacity can be restored by treatment with a reducing agent. Cigarette smoking may cause emphysema by inactivating alpha 1-antitrypsin through oxidation.

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Year:  1979        PMID： 316187     DOI： 10.1126/science.316187

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  41 in total

Review 1.  Acute effects of cigarette smoke on inflammation and oxidative stress: a review.

Authors:  H van der Vaart; D S Postma; W Timens; N H T ten Hacken
Journal:  Thorax       Date:  2004-08       Impact factor: 9.139

Review 2.  alpha-1-Antitrypsin and the pathogenesis of emphysema.

Authors:  R A Stockley
Journal:  Lung       Date:  1987       Impact factor: 2.584

3.  Sensitivity of heterozygous α1,6-fucosyltransferase knock-out mice to cigarette smoke-induced emphysema: implication of aberrant transforming growth factor-β signaling and matrix metalloproteinase gene expression.

Authors:  Congxiao Gao; Toshitaka Maeno; Fumi Ota; Manabu Ueno; Hiroaki Korekane; Shinji Takamatsu; Ken Shirato; Akio Matsumoto; Satoshi Kobayashi; Keiichi Yoshida; Shinobu Kitazume; Kazuaki Ohtsubo; Tomoko Betsuyaku; Naoyuki Taniguchi
Journal:  J Biol Chem       Date:  2012-03-20       Impact factor: 5.157

4.  Proteolysis by neutrophils. Relative importance of cell-substrate contact and oxidative inactivation of proteinase inhibitors in vitro.

Authors:  E J Campbell; R M Senior; J A McDonald; D L Cox
Journal:  J Clin Invest       Date:  1982-10       Impact factor: 14.808

5.  Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.

Authors:  H Carp; F Miller; J R Hoidal; A Janoff
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

Review 6.  Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema.

Authors:  Kevin Ni; Karina A Serban; Chanan Batra; Irina Petrache
Journal:  Ann Am Thorac Soc       Date:  2016-08

7.  A model of decreased functional alpha-1-proteinase inhibitor. Pulmonary pathology of dogs exposed to chloramine T.

Authors:  W R Abrams; A B Cohen; V V Damiano; A Eliraz; P Kimbel; D R Meranze; G Weinbaum
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808

8.  Potential mediator of inflammation. Phagocyte-derived oxidants suppress the elastase-inhibitory capacity of alpha 1-proteinase inhibitor in vitro.

Authors:  H Carp; A Janoff
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

9.  Elastase of U-937 monocytelike cells. Comparisons with elastases derived from human monocytes and neutrophils and murine macrophagelike cells.

Authors:  R M Senior; E J Campbell; J A Landis; F R Cox; C Kuhn; H S Koren
Journal:  J Clin Invest       Date:  1982-02       Impact factor: 14.808

Review 10.  alpha1-Antitrypsin deficiency . 6: new and emerging treatments for alpha1-antitrypsin deficiency.

Authors:  R A Sandhaus
Journal:  Thorax       Date:  2004-10       Impact factor: 9.139
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