Literature DB >> 31618330

Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy?

Mehmet Zahid Kocak1, Gulali Aktas1, Tuba T Duman1, Burcin M Atak1, Haluk Savli1.   

Abstract

OBJECTIVE: In this study, we aimed to analyze the relationship between serum uric acid (UA) and microalbuminuria as a marker of renal injury in type 2 diabetes mellitus.
METHODS: A total of 100 patients with type 2 diabetes mellitus were enrolled in the study. Participants were divided into two groups according to the urinary microalbumin/creatinine ratio: diabetic nephropathy and non-nephropathy group. UA and microalbuminuria were compared between the study groups.
RESULTS: Serum UA levels of diabetic nephropathy patients were significantly higher than those in the non-nephropathy group (UA in patients with diabetic nephropathy groups: 6.3 (1.82) mg/dl, UA in patients of the non-nephropathic group: 4.85 (1.92) mg/dl) (p<0.001). There was a correlation between microalbuminuria and UA (r=0.238). This correlation was statistically significant (p=0.017).
CONCLUSION: UA levels may be an important predictor of nephropathy in diabetic patients.

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Year:  2019        PMID: 31618330     DOI: 10.1590/1806-9282.65.9.1156

Source DB:  PubMed          Journal:  Rev Assoc Med Bras (1992)        ISSN: 0104-4230            Impact factor:   1.209


  9 in total

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6.  Association between serum uric acid and renal outcome in patients with biopsy-confirmed diabetic nephropathy.

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8.  The Association of Serum Uric Acid with Beta-Cell Function and Insulin Resistance in Nondiabetic Individuals: A Cross-Sectional Study.

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9.  Clinical Characteristics of Lipid Metabolism in Untreated Patients with Anti-MDA5 Antibody-Positive.

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  9 in total

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