Literature DB >> 31617897

Is Testicular Germ Cell Cancer Estrogen Dependent? The Role of Endocrine Disrupting Chemicals.

Patrick Fénichel1,2, Nicolas Chevalier1,2.   

Abstract

Testicular germ cell cancer (TGCC) is the most frequent cancer of the young male, with an increasing incidence worldwide. The pathogenesis and reasons for this increase remain unknown. However, epidemiological and experimental data have suggested that, similar to genital malformations and sperm impairment, it could result from the interaction of genetic and environmental factors including fetal exposure to endocrine-disrupting chemicals (EDCs) with estrogenic effects. In this review, we analyze the expression of classic and nonclassic estrogen receptors by TGCC cells, the way they may influence germ cell proliferation induced by EDCs, and discuss how this estrogen dependency supports the developmental and environmental hypothesis.
Copyright © 2019 Endocrine Society.

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Year:  2019        PMID： 31617897     DOI： 10.1210/en.2019-00486

Source DB:  PubMed          Journal:  Endocrinology        ISSN： 0013-7227            Impact factor:   4.736


  7 in total

1.  In Silico Approaches In Carcinogenicity Hazard Assessment: Current Status and Future Needs.

Authors:  Raymond R Tice; Arianna Bassan; Alexander Amberg; Lennart T Anger; Marc A Beal; Phillip Bellion; Romualdo Benigni; Jeffrey Birmingham; Alessandro Brigo; Frank Bringezu; Lidia Ceriani; Ian Crooks; Kevin Cross; Rosalie Elespuru; David M Faulkner; Marie C Fortin; Paul Fowler; Markus Frericks; Helga H J Gerets; Gloria D Jahnke; David R Jones; Naomi L Kruhlak; Elena Lo Piparo; Juan Lopez-Belmonte; Amarjit Luniwal; Alice Luu; Federica Madia; Serena Manganelli; Balasubramanian Manickam; Jordi Mestres; Amy L Mihalchik-Burhans; Louise Neilson; Arun Pandiri; Manuela Pavan; Cynthia V Rider; John P Rooney; Alejandra Trejo-Martin; Karen H Watanabe-Sailor; Angela T White; David Woolley; Glenn J Myatt
Journal:  Comput Toxicol       Date:  2021-09-23

Review 2.  The Role of ERα36 in Development and Tumor Malignancy.

Authors:  Charlène Thiebaut; Henri-Philippe Konan; Marie-Justine Guerquin; Amand Chesnel; Gabriel Livera; Muriel Le Romancer; Hélène Dumond
Journal:  Int J Mol Sci       Date:  2020-06-09       Impact factor: 5.923

Review 3.  GPER and Testicular Germ Cell Cancer.

Authors:  Nicolas Chevalier; Charlotte Hinault; Stephan Clavel; Rachel Paul-Bellon; Patrick Fenichel
Journal:  Front Endocrinol (Lausanne)       Date:  2021-01-26       Impact factor: 5.555

4.  Environmental chemicals in dog testes reflect their geographical source and may be associated with altered pathology.

Authors:  Rebecca N Sumner; Andrew Byers; Zulin Zhang; Jorgen S Agerholm; Lena Lindh; Gary C W England; Richard G Lea
Journal:  Sci Rep       Date:  2021-04-01       Impact factor: 4.379

5.  The changing tide of human fertility.

Authors:  R John Aitken
Journal:  Hum Reprod       Date:  2022-04-01       Impact factor: 6.918

6.  Incidence of testicular cancer in trans women using gender-affirming hormonal treatment: a nationwide cohort study.

Authors:  Iris de Nie; Chantal M Wiepjes; Christel J M de Blok; R Jeroen A van Moorselaar; Garry L S Pigot; Tim M van der Sluis; Ellis Barbé; Patrick van der Voorn; Norah M van Mello; Judith Huirne; Martin den Heijer
Journal:  BJU Int       Date:  2021-08-30       Impact factor: 5.969

Review 7.  Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell Tumors.

Authors:  Ratnakar Singh; Zeeshan Fazal; Sarah J Freemantle; Michael J Spinella
Journal:  Cancers (Basel)       Date:  2021-03-25       Impact factor: 6.639
  7 in total

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