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Literature DB >> 31616943

An allosteric inhibitor of SHP2 effectively targets PDGFRα-driven glioblastoma.

Bakhos A Tannous^1,2,3, Christian E Badr^1,2.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2019 PMID： 31616943 PMCID： PMC6827819 DOI： 10.1093/neuonc/noz176

Source DB: PubMed Journal: Neuro Oncol ISSN： 1522-8517 Impact factor: 12.300

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10 in total

1. Targeting PDGFRα-activated glioblastoma through specific inhibition of SHP-2-mediated signaling.

Authors: Youzhou Sang; Yanli Hou; Rongrong Cheng; Liang Zheng; Angel A Alvarez; Bo Hu; Shi-Yuan Cheng; Weiwei Zhang; Yanxin Li; Haizhong Feng
Journal: Neuro Oncol Date: 2019-11-04 Impact factor: 12.300

Review 2. The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway.

Authors: Marie Dance; Alexandra Montagner; Jean-Pierre Salles; Armelle Yart; Patrick Raynal
Journal: Cell Signal Date: 2007-10-11 Impact factor: 4.315

3. The somatic genomic landscape of glioblastoma.

Authors: Cameron W Brennan; Roel G W Verhaak; Aaron McKenna; Benito Campos; Houtan Noushmehr; Sofie R Salama; Siyuan Zheng; Debyani Chakravarty; J Zachary Sanborn; Samuel H Berman; Rameen Beroukhim; Brady Bernard; Chang-Jiun Wu; Giannicola Genovese; Ilya Shmulevich; Jill Barnholtz-Sloan; Lihua Zou; Rahulsimham Vegesna; Sachet A Shukla; Giovanni Ciriello; W K Yung; Wei Zhang; Carrie Sougnez; Tom Mikkelsen; Kenneth Aldape; Darell D Bigner; Erwin G Van Meir; Michael Prados; Andrew Sloan; Keith L Black; Jennifer Eschbacher; Gaetano Finocchiaro; William Friedman; David W Andrews; Abhijit Guha; Mary Iacocca; Brian P O'Neill; Greg Foltz; Jerome Myers; Daniel J Weisenberger; Robert Penny; Raju Kucherlapati; Charles M Perou; D Neil Hayes; Richard Gibbs; Marco Marra; Gordon B Mills; Eric Lander; Paul Spellman; Richard Wilson; Chris Sander; John Weinstein; Matthew Meyerson; Stacey Gabriel; Peter W Laird; David Haussler; Gad Getz; Lynda Chin
Journal: Cell Date: 2013-10-10 Impact factor: 41.582

4. Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling.

Authors: Tanveer S Batth; Moreno Papetti; Anamarija Pfeiffer; Maxim A X Tollenaere; Chiara Francavilla; Jesper V Olsen
Journal: Cell Rep Date: 2018-03-06 Impact factor: 9.423

5. SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans.

Authors: Kun-Wei Liu; Haizhong Feng; Robert Bachoo; Andrius Kazlauskas; Erin M Smith; Karen Symes; Ronald L Hamilton; Motoo Nagane; Ryo Nishikawa; Bo Hu; Shi-Yuan Cheng
Journal: J Clin Invest Date: 2011-03 Impact factor: 14.808

6. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.

Authors: Ying-Nan P Chen; Matthew J LaMarche; Ho Man Chan; Peter Fekkes; Jorge Garcia-Fortanet; Michael G Acker; Brandon Antonakos; Christine Hiu-Tung Chen; Zhouliang Chen; Vesselina G Cooke; Jason R Dobson; Zhan Deng; Feng Fei; Brant Firestone; Michelle Fodor; Cary Fridrich; Hui Gao; Denise Grunenfelder; Huai-Xiang Hao; Jaison Jacob; Samuel Ho; Kathy Hsiao; Zhao B Kang; Rajesh Karki; Mitsunori Kato; Jay Larrow; Laura R La Bonte; Francois Lenoir; Gang Liu; Shumei Liu; Dyuti Majumdar; Matthew J Meyer; Mark Palermo; Lawrence Perez; Minying Pu; Edmund Price; Christopher Quinn; Subarna Shakya; Michael D Shultz; Joanna Slisz; Kavitha Venkatesan; Ping Wang; Markus Warmuth; Sarah Williams; Guizhi Yang; Jing Yuan; Ji-Hu Zhang; Ping Zhu; Timothy Ramsey; Nicholas J Keen; William R Sellers; Travis Stams; Pascal D Fortin
Journal: Nature Date: 2016-06-29 Impact factor: 49.962

7. SHP-2-dependent mitogen-activated protein kinase activation regulates EGFRvIII but not wild-type epidermal growth factor receptor phosphorylation and glioblastoma cell survival.

Authors: Yi Zhan; Donald M O'Rourke
Journal: Cancer Res Date: 2004-11-15 Impact factor: 12.701