Julie Sommer1, Anne-Monique Nuyt2, François Audibert3, Véronique Dorval2, Sandrine Wavrant3, Anie Lapointe4, Gabriel Altit5. 1. Division of Neonatology, Department of Pediatrics, Hôpitaux Universitaires de Genève - Université de Genève, Geneva, Switzerland. 2. Division of Neonatology, Department of Pediatrics, CHU Sainte-Justine-Université de Montréal, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada. 3. Department of Obstetrics and Gynecology, CHU Sainte-Justine-Université de Montréal, Montreal, QC, Canada. 4. Division of Neonatology, Department of Pediatrics, CHU Sainte-Justine-Université de Montréal, 3175, Chemin de la Côte-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada. anie.lapointe@umontreal.ca. 5. Division of Neonatology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre, McGill University, 1001 Décarie, B05.2513, Montreal, QC, Canada. Gabriel.altit@mcgill.ca.
Abstract
OBJECTIVE: Describe renal function of preterm infants <29 weeks of gestational age (GA) with twin-twin transfusion syndrome (TTTS) who received laser therapy. DESIGN: Retrospective analysis of premature TTTS compared with dichorionic-diamniotic (di-di) twins from 2006 to 2015. Primary outcome was biomarkers of renal injury. RESULTS: Thirty-three TTTS-laser and 101 di-di newborns with similar GA at birth (26.4 ± 1.4 vs 26.9 ± 1.6 weeks, p = 0.07) were included. Creatinine and urea levels were higher in TTTS-laser group at day of life (DOL) 2-7 (123.5 ± 12.4 vs 75.8 ± 2 μmol/L, p = 0.0001 and 11.9 ± 1.1 mmol/L vs 8.7 ± 0.3 mmol/L, p = 0.0001) and DOL 8-14, (98.1 ± 14.2 vs 64.8 ± 2.3 μmol/L, p = 0.0001 and 9.1 ± 1.2 vs 5.4 ± 0.3 mmol/L, p = 0.0001). There was a significant effect of TTTS status on creatinine level at DOL 8-14. CONCLUSION: In extremely preterm with TTTS treated by laser, biomarkers of renal function were higher compared with di-di twins in the first 2 weeks of life.
OBJECTIVE: Describe renal function of preterm infants <29 weeks of gestational age (GA) with twin-twin transfusion syndrome (TTTS) who received laser therapy. DESIGN: Retrospective analysis of premature TTTS compared with dichorionic-diamniotic (di-di) twins from 2006 to 2015. Primary outcome was biomarkers of renal injury. RESULTS: Thirty-three TTTS-laser and 101 di-di newborns with similar GA at birth (26.4 ± 1.4 vs 26.9 ± 1.6 weeks, p = 0.07) were included. Creatinine and urea levels were higher in TTTS-laser group at day of life (DOL) 2-7 (123.5 ± 12.4 vs 75.8 ± 2 μmol/L, p = 0.0001 and 11.9 ± 1.1 mmol/L vs 8.7 ± 0.3 mmol/L, p = 0.0001) and DOL 8-14, (98.1 ± 14.2 vs 64.8 ± 2.3 μmol/L, p = 0.0001 and 9.1 ± 1.2 vs 5.4 ± 0.3 mmol/L, p = 0.0001). There was a significant effect of TTTS status on creatinine level at DOL 8-14. CONCLUSION: In extremely preterm with TTTS treated by laser, biomarkers of renal function were higher compared with di-di twins in the first 2 weeks of life.
Authors: I Mercanti; A Boivin; B Wo; V Vlieghe; C Le Ray; F Audibert; J-C Fouron; L Leduc; A M Nuyt Journal: J Perinatol Date: 2011-01-20 Impact factor: 2.521