Literature DB >> 31613956

High Rates of Hepatitis B Virus (HBV) Functional Cure Among Human Immunodeficiency Virus-HBV Coinfected Patients on Antiretroviral Therapy in Zambia.

Belinda V Chihota1,2, Gilles Wandeler2,3, Roma Chilengi1, Lloyd Mulenga4,5, Raymond T Chung6, Debika Bhattacharya7, Mathias Egger2,8, Michael J Vinikoor1,4,9.   

Abstract

Among 284 human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfected adults starting tenofovir-based antiretroviral therapy (ART) in Zambia, median baseline CD4+ count was 202 cells/mm3 and 41.6% were hepatitis B e-antigen positive. Within 2 years of therapy, 29 (10.2%) participants experienced HBV functional cure (confirmed loss of hepatitis B surface antigen). In multivariable analysis, baseline CD4 count <350 cells/mm3, female sex, and lower baseline HBV deoxyribonucleic acid were associated with increased odds of functional cure. Immune recovery during HIV-HBV treatment with ART may drive higher rates of functional cure than during HBV monoinfection treatment. Understanding the mechanisms underlying this phenomenon could inform immunomodulatory therapies for HBV cure.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Africa; HBV functional cure; HIV-HBV coinfection; antiretroviral therapy outcomes

Mesh：

Substances：

Year:  2020        PMID： 31613956      PMCID： PMC7184905          DOI： 10.1093/infdis/jiz450

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

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Authors:  Adam J Gehring
Journal:  Best Pract Res Clin Gastroenterol       Date:  2017-05-25       Impact factor: 3.043

Review 2.  HIV-hepatitis B virus coinfection: epidemiology, pathogenesis, and treatment.

Authors:  Kasha P Singh; Megan Crane; Jennifer Audsley; Anchalee Avihingsanon; Joe Sasadeusz; Sharon R Lewin
Journal:  AIDS       Date:  2017-09-24       Impact factor: 4.177

3.  New Direct-Acting Antiviral Agents and Immunomodulators for Hepatitis B Virus Infection.

Authors:  Marion G Peters; Stephen Locarnini
Journal:  Gastroenterol Hepatol (N Y)       Date:  2017-06

4.  Reduced hepatitis B virus (HBV)-specific CD4+ T-cell responses in human immunodeficiency virus type 1-HBV-coinfected individuals receiving HBV-active antiretroviral therapy.

Authors:  J Judy Chang; Fiona Wightman; Angeline Bartholomeusz; Anna Ayres; Stephen J Kent; Joseph Sasadeusz; Sharon R Lewin
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

5.  Point-of-Care Urine Ethyl Glucuronide Testing to Detect Alcohol Use Among HIV-Hepatitis B Virus Coinfected Adults in Zambia.

Authors:  Michael J Vinikoor; Zude Zyambo; Monde Muyoyeta; Geetanjali Chander; Michael S Saag; Karen Cropsey
Journal:  AIDS Behav       Date:  2018-07

6.  Factors Associated With Rates of HBsAg Seroclearance in Adults With Chronic HBV Infection: A Systematic Review and Meta-analysis.

Authors:  Yee Hui Yeo; Hsiu J Ho; Hwai-I Yang; Tai-Chung Tseng; Tetsuya Hosaka; Huy N Trinh; Min-Sun Kwak; Young Min Park; James Yan Yue Fung; Maria Buti; Manuel Rodríguez; Sombat Treeprasertsuk; Carmen Monica Preda; Teerapat Ungtrakul; Phunchai Charatcharoenwitthaya; Xiangyong Li; Jiayi Li; Jian Zhang; Michael Huan Le; Bin Wei; Biyao Zou; An Le; Donghak Jeong; Nicholas Chien; Leslie Kam; Chiao-Chin Lee; Mar Riveiro-Barciela; Doina Istratescu; Tassanee Sriprayoon; Yutian Chong; Tawesak Tanwandee; Mariko Kobayashi; Fumitaka Suzuki; Man-Fung Yuen; Hyo-Suk Lee; Jia-Horng Kao; Anna S Lok; Chun-Ying Wu; Mindie H Nguyen
Journal:  Gastroenterology       Date:  2018-10-17       Impact factor: 22.682

7.  HBsAg seroclearance after nucleoside analogue therapy in patients with chronic hepatitis B: clinical outcomes and durability.

Authors:  Gi-Ae Kim; Young-Suk Lim; Jihyun An; Danbi Lee; Ju Hyun Shim; Kang Mo Kim; Han Chu Lee; Young-Hwa Chung; Yung Sang Lee; Dong Jin Suh
Journal:  Gut       Date:  2013-10-25       Impact factor: 23.059

8.  Higher Mortality Despite Early Antiretroviral Therapy in Human Immunodeficiency Virus and Hepatitis B Virus (HBV)-Coinfected Patients With High HBV Replication.

Authors:  Gérard-Menan Kouamé; Anders Boyd; Raoul Moh; Anani Badje; Delphine Gabillard; Eric Ouattara; Jean-Baptiste Ntakpe; Arlette Emième; Sarah Maylin; Mariama Abdou Chekaraou; Serge-Paul Eholié; Fabien Zoulim; Karine Lacombe; Xavier Anglaret; Christine Danel
Journal:  Clin Infect Dis       Date:  2018-01-06       Impact factor: 9.079

9.  Impact of Antiretroviral Therapy on Liver Fibrosis Among Human Immunodeficiency Virus-Infected Adults With and Without HBV Coinfection in Zambia.

Authors:  Michael J Vinikoor; Edford Sinkala; Roma Chilengi; Lloyd B Mulenga; Benjamin H Chi; Zude Zyambo; Christopher J Hoffmann; Michael S Saag; Mary-Ann Davies; Matthias Egger; Gilles Wandeler
Journal:  Clin Infect Dis       Date:  2017-05-15       Impact factor: 9.079

10.  Quantitative HBsAg and HBeAg predict hepatitis B seroconversion after initiation of HAART in HIV-HBV coinfected individuals.

Authors:  Gail V Matthews; Rachel J Ali; Anchalee Avihingsanon; Janaki Amin; Rachel Hammond; Scott Bowden; Sharon R Lewin; Joe Sasadeusz; Margaret Littlejohn; Stephen L Locarnini; Kiat Ruxrungtham; Gregory J Dore
Journal:  PLoS One       Date:  2013-04-09       Impact factor: 3.240
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  9 in total

Review 1.  Immune Mechanisms Underlying Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B Patients With Viral Coinfection.

Authors:  Shuling Wu; Wei Yi; Yuanjiao Gao; Wen Deng; Xiaoyue Bi; Yanjie Lin; Liu Yang; Yao Lu; Ruyu Liu; Min Chang; Ge Shen; Leiping Hu; Lu Zhang; Minghui Li; Yao Xie
Journal:  Front Immunol       Date:  2022-05-11       Impact factor: 8.786

2.  Chronic Hepatitis B and HIV Coinfection: A Continuing Challenge in the Era of Antiretroviral Therapy.

Authors:  H Nina Kim
Journal:  Curr Hepatol Rep       Date:  2020-09-16

3.  Prevalence of HIV/hepatitis B and HIV/hepatitis C coinfection among people of East, South, Central and West African ancestry in the United Kingdom.

Authors:  Rachel Hung; Nisha Patel; Julie Fox; Catherine Cosgrove; Sarah L Pett; Fiona Burns; Andrew Ustianowski; Melanie Rosenvinge; Sanjay Bhagani; Geoff Dusheiko; Kate Childs; Frank A Post
Journal:  AIDS       Date:  2021-08-01       Impact factor: 4.177

4.  A Prospective Study Evaluating Changes in Histology, Clinical and Virologic Outcomes in HBV-HIV Co-infected Adults in North America.

Authors:  Richard K Sterling; Wendy C King; Mandana Khalili; Raymond T Chung; Mark Sulkowski; Mamta K Jain; Mauricio Lisker-Melman; Marc G Ghany; David K Wong; Amanda S Hinerman; Atul K Bhan; Abdus S Wahed; David E Kleiner
Journal:  Hepatology       Date:  2021-08-25       Impact factor: 17.298

5.  Elimination of Viral Hepatitis in Low and Middle-Income Countries: Epidemiological Research Gaps.

Authors:  Antoine Jaquet; Guy Muula; Didier K Ekouevi; Gilles Wandeler
Journal:  Curr Epidemiol Rep       Date:  2021-07-31

Review 6.  Sexual Dimorphism in Chronic Hepatitis B Virus (HBV) Infection: Evidence to Inform Elimination Efforts.

Authors:  Robin Brown; Philip Goulder; Philippa C Matthews
Journal:  Wellcome Open Res       Date:  2022-04-26

Review 7.  Management of Chronic Hepatitis B in HIV-Coinfected Patients.

Authors:  Massimo Fasano; Maria Cristina Poliseno; Josè Ramon Fiore; Sergio Lo Caputo; Antonella D'Arminio Monforte; Teresa Antonia Santantonio
Journal:  Viruses       Date:  2022-09-13       Impact factor: 5.818

8.  Hepatitis B virus infection among men who have sex with men and transgender women living with or at risk for HIV: a cross sectional study in Abuja and Lagos, Nigeria.

Authors:  Olusegun A Adeyemi; Andrew Mitchell; Ashley Shutt; Trevor A Crowell; Nicaise Ndembi; Afoke Kokogho; Habib O Ramadhani; Merlin L Robb; Stefan D Baral; Julie A Ake; Manhattan E Charurat; Sheila Peel; Rebecca G Nowak
Journal:  BMC Infect Dis       Date:  2021-07-06       Impact factor: 3.090

Review 9.  HBV Infection in HIV-Driven Immune Suppression.

Authors:  Loredana Sarmati; Vincenzo Malagnino
Journal:  Viruses       Date:  2019-11-19       Impact factor: 5.048
  9 in total

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