Literature DB >> 31613627

ZnCl2-Mediated Double Addition of Dialkylphosphite to Nitriles for the Synthesis of 1-Aminobisphosphonates.

Babak Kaboudin1, Hesam Esfandiari1, Atieh Moradi1, Foad Kazemi1, Hiroshi Aoyama2.   

Abstract

In this study, the double addition of dialkylphosphite to nitriles in a ZnCl2/Et3N system is described. The reaction was conveniently and directly used for the synthesis of biologically important 1-aminobisphosphonates (ABPs) from nitriles. The one-pot synthesis of 1-aminobisphosphonates from aldehydes via the in situ generation of nitriles is also described.

Entities:  

Year:  2019        PMID： 31613627     DOI： 10.1021/acs.joc.9b02298

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

Review 1.  Hydroxy- and Amino-Phosphonates and -Bisphosphonates: Synthetic Methods and Their Biological Applications.

Authors:  Babak Kaboudin; Payam Daliri; Samaneh Faghih; Hesam Esfandiari
Journal:  Front Chem       Date:  2022-06-01       Impact factor: 5.545

2.  One-Pot and Catalyst-Free Transformation of N-Protected 1-Amino-1-Ethoxyalkylphosphonates into Bisphosphonic Analogs of Protein and Non-Protein α-Amino Acids.

Authors:  Anna Kuźnik; Dominika Kozicka; Wioleta Hawranek; Karolina Socha; Karol Erfurt
Journal:  Molecules       Date:  2022-06-02       Impact factor: 4.927
  2 in total

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