| Literature DB >> 31612821 |
Adeeb Shehzad1, Vijaya Ravinayagam2, Hamad AlRumaih3, Meneerah Aljafary4, Dana Almohazey5, Sarah Almofty5, Noor A Al-Rashid1, Ebtesam A Al-Suhaimi4,5.
Abstract
The in-vitro experimental model for the development of cancer therapeutics has always been challenging. Recently, the scientific revolution has improved cell culturing techniques by applying three dimensional (3D) culture system, which provides a similar physiologically relevant in-vivo model for studying various diseases including cancer. In particular, cancer cells exhibiting in-vivo behavior in a model of 3D cell culture is a more accurate cell culture model to test the effectiveness of anticancer drugs or characterization of cancer cells in comparison with two dimensional (2D) monolayer. This study underpins various factors that cause resistance to anticancer drugs in forms of spheroids in 3D in-vitro cell culture and also outlines key challenges and possible solutions for the future development of these systems. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: 2D monolayer; 3D cell culture; cancer therapy; drug discovery; drug resistance.; spheroid
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Year: 2019 PMID： 31612821 DOI： 10.2174/1381612825666191014163923
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116