| Literature DB >> 31612386 |
Jia-Xuan Qin1, Zong-Long Cai2, Yu-Feng Yang1, Jin-Chun Xing1, Xuan Zhuang3.
Abstract
It has been reported that c-KIT ligand (KITLG) gene polymorphisms may be associated with testicular germ cell tumors (TGCT). Owing to mixed and inconclusive results, we conducted a systematic review and meta-analysis to summarize and clarify this association. A systematic search of studies on the association between KITLG gene polymorphisms and TGCT susceptibility was conducted in databases. Odds ratios and 95% confidence intervals were used to pool the effect size. Six articles were included in our systematic review and meta-analysis. Compared with adenine (A), KITLG rs995030 guanine (G) might be associated with increased risk of TGCT. There are insufficient data to fully confirm the association between KITLG rs4474514 and TGCT susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis.Entities:
Keywords: c-KIT ligand; meta-analysis; single nucleotide polymorphisms; testicular germ cell tumors
Mesh：
Substances：
Year: 2019 PMID： 31612386 DOI： 10.1007/s11596-019-2095-2
Source DB: PubMed Journal: Curr Med Sci ISSN： 2523-899X