Literature DB >> 31612170

Polymyxin derivatives as broad-spectrum antibiotic agents.

Ma Su1, Minghui Wang1, Yuzhu Hong2, Alekhya Nimmagadda1, Ning Shen2, Yan Shi1, Ruixuan Gao1, En Zhang3, Chuanhai Cao2, Jianfeng Cai1.   

Abstract

We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.

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Year:  2019        PMID： 31612170     DOI： 10.1039/c9cc06908a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

Review 1.  Topical Antibiofilm Agents With Potential Utility in the Treatment of Chronic Rhinosinusitis: A Narrative Review.

Authors:  Samuel J M Hale; Brett Wagner Mackenzie; Christian A Lux; Kristi Biswas; Raymond Kim; Richard G Douglas
Journal:  Front Pharmacol       Date:  2022-06-13       Impact factor: 5.988

2.  Dimeric lipo-α/sulfono-γ-AA hybrid peptides as broad-spectrum antibiotic agents.

Authors:  Lulu Wei; Ruixuan Gao; Minghui Wang; Yafeng Wang; Yan Shi; Meng Gu; Jianfeng Cai
Journal:  Biomater Sci       Date:  2021-05-04       Impact factor: 6.843

3.  Bi-Functional Alginate Oligosaccharide-Polymyxin Conjugates for Improved Treatment of Multidrug-Resistant Gram-Negative Bacterial Infections.

Authors:  Joana Stokniene; Lydia C Powell; Olav A Aarstad; Finn L Aachmann; Philip D Rye; Katja E Hill; David W Thomas; Elaine L Ferguson
Journal:  Pharmaceutics       Date:  2020-11-11       Impact factor: 6.321
  3 in total

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