Patrick J Peebles1, Theresa M Duello2, Jens C Eickhoff3, Ryan M McAdams3. 1. Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. pjpeebles@wisc.edu. 2. Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. 3. Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Abstract
OBJECTIVE: To identify antenatal and intrapartum risk factors for neonatal hypoxic ischemic encephalopathy (HIE). STUDY DESIGN: A single center, retrospective cohort study was conducted for 25,494 singleton births ≥36 weeks' gestation born between 2009 and 2016. Univariate and multivariate analyses were performed to identify risk factors for HIE. RESULTS: Thirty-seven infants met HIE inclusion criteria. Independent antenatal risk factors included primigravida, previous fetal death/stillbirth, antidepressant use, illicit drug use, Rh sensitization, and adjusted gestational weight gain >13.6 kg. Independent intrapartum risk factors identified were placental abruption, ruptured uterus, moderate-to-heavy meconium stained amniotic fluid, and delivery by cesarean-section. An intrapartum risk factor was present in 70.3% of the HIE group compared with 29.6% of the non-HIE group. CONCLUSION: Intrapartum period risk factors appear to be important for the development of HIE. Gestational weight gain may serve as an important modifiable factor to reduce the risk of HIE.
OBJECTIVE: To identify antenatal and intrapartum risk factors for neonatal hypoxic ischemicencephalopathy (HIE). STUDY DESIGN: A single center, retrospective cohort study was conducted for 25,494 singleton births ≥36 weeks' gestation born between 2009 and 2016. Univariate and multivariate analyses were performed to identify risk factors for HIE. RESULTS: Thirty-seven infants met HIE inclusion criteria. Independent antenatal risk factors included primigravida, previous fetal death/stillbirth, antidepressant use, illicit drug use, Rh sensitization, and adjusted gestational weight gain >13.6 kg. Independent intrapartum risk factors identified were placental abruption, ruptured uterus, moderate-to-heavy meconium stained amniotic fluid, and delivery by cesarean-section. An intrapartum risk factor was present in 70.3% of the HIE group compared with 29.6% of the non-HIE group. CONCLUSION: Intrapartum period risk factors appear to be important for the development of HIE. Gestational weight gain may serve as an important modifiable factor to reduce the risk of HIE.
Authors: Sujith Kumar Reddy Gurram Venkata; Prakesh S Shah; Marc Beltempo; Eugene Yoon; Stephen Wood; Matthew Hicks; Thierry Daboval; Jonathan Wong; Pia Wintermark; Khorshid Mohammad Journal: Childs Nerv Syst Date: 2022-06-08 Impact factor: 1.532
Authors: Tina Dempsey; Huong Lien Nguyen; Huong Thu Nguyen; Xuan Anh Bui; Phuong Thi Thu Pham; Toan K Nguyen; Francesco Cavallin; Daniele Trevisanuto; Susanna Myrnerts Höök; Nicolas Pejovic; Mats Blennow; Linus Olson; Hien Vu; Anh Duy Nguyen; Tobias Alfvén Journal: Children (Basel) Date: 2022-02-28