Literature DB >> 31611355

Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs.

Aaron S Devanathan1, Jason R Pirone1, Ramesh Akkina2, Leila Remling-Mulder2, Paul Luciw3, Lourdes Adamson3, J Victor Garcia4, Martina Kovarova4, Nicole R White1, Amanda P Schauer1, Kimberly Blake1, Craig Sykes1, Erin M Burgunder1, Nithya Srinivas1, Elias P Rosen1, Angela D M Kashuba5,4.   

Abstract

For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  HIV; antiretrovirals; pharmacokinetics; species differences; tissue reservoirs

Year:  2019        PMID： 31611355      PMCID： PMC7187610          DOI： 10.1128/AAC.01639-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans.

Authors:  Erin Burgunder; John K Fallon; Nicole White; Amanda P Schauer; Craig Sykes; Leila Remling-Mulder; Martina Kovarova; Lourdes Adamson; Paul Luciw; J Victor Garcia; Ramesh Akkina; Philip C Smith; Angela D M Kashuba
Journal:  J Pharmacol Exp Ther       Date:  2019-06-24       Impact factor: 4.030

2.  A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine.

Authors:  Mackenzie L Cottrell; Kuo H Yang; Heather M A Prince; Craig Sykes; Nicole White; Stephanie Malone; Evan S Dellon; Ryan D Madanick; Nicholas J Shaheen; Michael G Hudgens; Jacob Wulff; Kristine B Patterson; Julie A E Nelson; Angela D M Kashuba
Journal:  J Infect Dis       Date:  2016-02-24       Impact factor: 5.226

3.  Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs.

Authors:  Corbin G Thompson; Mark T Bokhart; Craig Sykes; Lourdes Adamson; Yuri Fedoriw; Paul A Luciw; David C Muddiman; Angela D M Kashuba; Elias P Rosen
Journal:  Antimicrob Agents Chemother       Date:  2015-03-02       Impact factor: 5.191

Review 4.  New generation humanized mice for virus research: comparative aspects and future prospects.

Authors:  Ramesh Akkina
Journal:  Virology       Date:  2013-01-05       Impact factor: 3.616

5.  Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection.

Authors:  Joseph J Mattapallil; Daniel C Douek; Brenna Hill; Yoshiaki Nishimura; Malcolm Martin; Mario Roederer
Journal:  Nature       Date:  2005-04-28       Impact factor: 49.962

6.  Lymphoid organs function as major reservoirs for human immunodeficiency virus.

Authors:  G Pantaleo; C Graziosi; L Butini; P A Pizzo; S M Schnittman; D P Kotler; A S Fauci
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

Review 7.  Role and modulation of drug transporters in HIV-1 therapy.

Authors:  Camille Alam; Sana-Kay Whyte-Allman; Amila Omeragic; Reina Bendayan
Journal:  Adv Drug Deliv Rev       Date:  2016-05-13       Impact factor: 15.470

8.  Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species.

Authors:  Nithya Srinivas; Elias P Rosen; William M Gilliland; Martina Kovarova; Leila Remling-Mulder; Gabriela De La Cruz; Nicole White; Lourdes Adamson; Amanda P Schauer; Craig Sykes; Paul Luciw; J Victor Garcia; Ramesh Akkina; Angela D M Kashuba
Journal:  Xenobiotica       Date:  2018-12-17       Impact factor: 1.908

9.  Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model.

Authors:  C Preston Neff; Thomas Ndolo; Apurva Tandon; Yuichiro Habu; Ramesh Akkina
Journal:  PLoS One       Date:  2010-12-21       Impact factor: 3.240

10.  A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.

Authors:  Iart Luca Shytaj; Sandro Norelli; Barbara Chirullo; Alessandro Della Corte; Matt Collins; Jake Yalley-Ogunro; Jack Greenhouse; Nunzio Iraci; Edward P Acosta; Maria Letizia Barreca; Mark G Lewis; Andrea Savarino
Journal:  PLoS Pathog       Date:  2012-06-21       Impact factor: 6.823
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  7 in total

1.  Antiretroviral Penetration and Drug Transporter Concentrations in the Spleens of Three Preclinical Animal Models and Humans.

Authors:  Aaron S Devanathan; John K Fallon; Nicole R White; Amanda P Schauer; Brian Van Horne; Kimberly Blake; Craig Sykes; Martina Kovarova; Lourdes Adamson; Leila Remling-Mulder; Paul Luciw; J Victor Garcia; Ramesh Akkina; Jason R Pirone; Philip C Smith; Angela D M Kashuba
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191

2.  Quantitative Imaging Analysis of the Spatial Relationship between Antiretrovirals, Reverse Transcriptase Simian-Human Immunodeficiency Virus RNA, and Fibrosis in the Spleens of Nonhuman Primates.

Authors:  Aaron S Devanathan; Nicole R White; Yury Desyaterik; Gabriela De la Cruz; Michael Nekorchuk; Margaret Terry; Kathleen Busman-Sahay; Lourdes Adamson; Paul Luciw; Yuri Fedoriw; Jacob D Estes; Elias P Rosen; Angela D M Kashuba
Journal:  Antimicrob Agents Chemother       Date:  2022-07-20       Impact factor: 5.938

Review 3.  Lessons for Understanding Central Nervous System HIV Reservoirs from the Last Gift Program.

Authors:  Patricia K Riggs; Antoine Chaillon; Guochun Jiang; Scott L Letendre; Yuyang Tang; Jeff Taylor; Andrew Kaytes; Davey M Smith; Karine Dubé; Sara Gianella
Journal:  Curr HIV/AIDS Rep       Date:  2022-10-19       Impact factor: 5.495

Review 4.  Treating viruses in the brain: Perspectives from NeuroAIDS.

Authors:  Melanie R Nicol; MaryPeace McRae
Journal:  Neurosci Lett       Date:  2021-01-30       Impact factor: 3.046

Review 5.  Pharmacology of HIV Cure: Site of Action.

Authors:  Aaron S Devanathan; Mackenzie L Cottrell
Journal:  Clin Pharmacol Ther       Date:  2021-03-05       Impact factor: 6.875

6.  Human Immunodeficiency Virus Persistence in the Spleen: Opportunities for Pharmacologic Intervention.

Authors:  Aaron S Devanathan; Angela D M Kashuba
Journal:  AIDS Res Hum Retroviruses       Date:  2021-02-22       Impact factor: 1.723

7.  Antiretroviral drug exposure in lymph nodes is heterogeneous and drug dependent.

Authors:  Elias P Rosen; Claire Deleage; Nicole White; Craig Sykes; Catherine Brands; Lourdes Adamson; Paul Luciw; Jacob D Estes; Angela D M Kashuba
Journal:  J Int AIDS Soc       Date:  2022-04       Impact factor: 6.707
  7 in total

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