Tong Su1, Xiaonan Shao2, Xiaopu Zhang3, Chengjian Yang4, Xiaoliang Shao5. 1. Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China. 2. Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China. 3. Department of Neurology, The Third People's Hospital of Changzhou, Changzhou, 213001, Jiangsu, China. 4. Department of Cardiology, The Second People's Hospital of Wuxi Affiliated to Nanjing Medical University, Wuxi, 214000, Jiangsu, China. Electronic address: 326061944@qq.com. 5. Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China. Electronic address: xl_shao@126.com.
Abstract
BACKGROUND: To explore the significance of circulating miRNA-1 (miR-1) released within 3 h after the onset of acute chest pain in the diagnosis and prognosis of acute myocardial infarction (AMI). METHODS: A total of 337 patients with acute chest pain within 3 h were enrolled in this study and divided into AMI group and non-AMI group. The AMI diagnostic efficacy of miR-1 was determined and compared with that of cardiac troponin I (cTnI). The patients were followed up for 720 d after treatment. The significance of circulating miR-1 in AMI prognosis was assessed using univariate and COX regression analysis. RESULTS: There were 174 patients in AMI group, 163 in non-AMI group. Circulating miR-1 level was significantly higher in AMI group than in non-AMI group (P < 0.001). The AMI diagnostic efficacy of miR-1 and cTnI were similar (P > 0.05). We established two AMI diagnostic models, the AUC values of which were larger than that of cTnI or miR-1 (P < 0.05). When miR-1 combined with CK-MB, cTnI, and other clinical and laboratory parameters (model 2), the AUC was the largest (AUC: 0.961) and had the highest diagnostic efficiency. Circulating miR-1, Killip classification, and treatment method were influencing factors for AMI prognosis (P < 0.05). CONCLUSIONS: Circulating miR-1 within 3 h of acute chest pain has the potential diagnostic value for AMI, and which is an independent risk factor for the prognosis of AMI and can be used to predict AMI prognosis.
BACKGROUND: To explore the significance of circulating miRNA-1 (miR-1) released within 3 h after the onset of acute chest pain in the diagnosis and prognosis of acute myocardial infarction (AMI). METHODS: A total of 337 patients with acute chest pain within 3 h were enrolled in this study and divided into AMI group and non-AMI group. The AMI diagnostic efficacy of miR-1 was determined and compared with that of cardiac troponin I (cTnI). The patients were followed up for 720 d after treatment. The significance of circulating miR-1 in AMI prognosis was assessed using univariate and COX regression analysis. RESULTS: There were 174 patients in AMI group, 163 in non-AMI group. Circulating miR-1 level was significantly higher in AMI group than in non-AMI group (P < 0.001). The AMI diagnostic efficacy of miR-1 and cTnI were similar (P > 0.05). We established two AMI diagnostic models, the AUC values of which were larger than that of cTnI or miR-1 (P < 0.05). When miR-1 combined with CK-MB, cTnI, and other clinical and laboratory parameters (model 2), the AUC was the largest (AUC: 0.961) and had the highest diagnostic efficiency. Circulating miR-1, Killip classification, and treatment method were influencing factors for AMI prognosis (P < 0.05). CONCLUSIONS: Circulating miR-1 within 3 h of acute chest pain has the potential diagnostic value for AMI, and which is an independent risk factor for the prognosis of AMI and can be used to predict AMI prognosis.