Priscilla A Amofa Sr1, Brittany DeFeis1, Liselotte De Wit1, Deirdre O'Shea1, Andrea Mejia1, Melanie Chandler2, Dona E C Locke3, Julie Fields4, Vaishali Phatak5, Pamela M Dean6, Julia Crook7, Glenn Smith1,4. 1. Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA. 2. Department of Psychiatry and Psychology, Mayo Clinic Florida, Jacksonville, FL, USA. 3. Department of Psychiatry and Psychology, Mayo Clinic Arizona, Scottsdale, AZ, USA. 4. Department of Psychiatry and Psychology, Mayo Clinic Minnesota, Rochester, MN, USA. 5. Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA. 6. Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. 7. Division of Biomedical Statistics and Informatics, Mayo Clinic Florida, Jacksonville, FL, USA.
Abstract
Objective: Behavioral interventions during early memory decline hold promise in delaying the development of dementia. In the present study, participants in a multimodal behavioral intervention study were assessed for post-intervention adherence and predictors of adherence. Methods: Participants (N = 272, mean age = 75.04 ± 7.54) diagnosed with amnestic Mild Cognitive Impairment (aMCI) were assigned to intervention groups receiving four out of five behavioral intervention components, including yoga, memory compensation training, computerized cognitive training, support groups, and/or wellness education. Length of the intervention was 10 days, 4 h per day, with post-intervention follow-up at 6, 12, and 18 months. Results: Two-hundred and thirty-seven participants completed the 6-month post-intervention follow-up measures, 228 participants completed the 12-month measures, and 218 participants completed the 18-month measures. Participants fully adhered to a mean of 2 out of the 4 taught intervention components. Eighty-nine percent of participants were at least partially adherent to one or more taught intervention components at 6-, 12-, and 18-month post-intervention follow-up. Physical activity was the most adhered to intervention while group support was the least adhered to intervention across all three follow-up time-points. Higher educational level, higher baseline depressive symptoms, higher baseline global cognitive functioning, and better baseline and concurrent functional abilities were associated post-intervention adherence. Conclusion: Changes in functional abilities are associated with disease progression among persons with aMCI. In the present study, individuals with aMCI who have higher education, higher depressive symptoms, and better baseline functioning abilities are more likely to adhere to behavioral intervention components over time. Post-intervention adherence also associates with concurrent daily function.
RCT Entities:
Objective: Behavioral interventions during early memory decline hold promise in delaying the development of dementia. In the present study, participants in a multimodal behavioral intervention study were assessed for post-intervention adherence and predictors of adherence. Methods:Participants (N = 272, mean age = 75.04 ± 7.54) diagnosed with amnestic Mild Cognitive Impairment (aMCI) were assigned to intervention groups receiving four out of five behavioral intervention components, including yoga, memory compensation training, computerized cognitive training, support groups, and/or wellness education. Length of the intervention was 10 days, 4 h per day, with post-intervention follow-up at 6, 12, and 18 months. Results: Two-hundred and thirty-seven participants completed the 6-month post-intervention follow-up measures, 228 participants completed the 12-month measures, and 218 participants completed the 18-month measures. Participants fully adhered to a mean of 2 out of the 4 taught intervention components. Eighty-nine percent of participants were at least partially adherent to one or more taught intervention components at 6-, 12-, and 18-month post-intervention follow-up. Physical activity was the most adhered to intervention while group support was the least adhered to intervention across all three follow-up time-points. Higher educational level, higher baseline depressive symptoms, higher baseline global cognitive functioning, and better baseline and concurrent functional abilities were associated post-intervention adherence. Conclusion: Changes in functional abilities are associated with disease progression among persons with aMCI. In the present study, individuals with aMCI who have higher education, higher depressive symptoms, and better baseline functioning abilities are more likely to adhere to behavioral intervention components over time. Post-intervention adherence also associates with concurrent daily function.
Authors: Zhe He; Shubo Tian; Ankita Singh; Shayok Chakraborty; Shenghao Zhang; Mia Liza A Lustria; Neil Charness; Nelson A Roque; Erin R Harrell; Walter R Boot Journal: Inf Process Manag Date: 2022-07-21 Impact factor: 7.466
Authors: Anne L Shandera-Ochsner; Melanie J Chandler; Dona E Locke; Colleen T Ball; Julia E Crook; Vaishali S Phatak; Glenn E Smith Journal: J Int Neuropsychol Soc Date: 2021-07-26 Impact factor: 2.892
Authors: Aladdin H Shadyab; Andrea Z LaCroix; Howard H Feldman; Christopher H van Dyck; Ozioma C Okonkwo; Steven P Tam; J Kaci Fairchild; Kathleen A Welsh-Bohmer; Genevieve Matthews; Daniel Bennett; Alexandre A Shadyab; Kimberly A Schafer; Rosemary H Morrison; Sean A Kipperman; Jennifer Mason; Donna Tan; Ronald G Thomas; Carl W Cotman; Laura D Baker Journal: Alzheimers Dement Date: 2021-07-23 Impact factor: 16.655