| Literature DB >> 31608523 |
Yang Long1,2, Yiming Ding2,3, Hai Wu2,3, Chunlei Qu2,3, Hong Liang2,3, Min Zhang2,3, Xiaoli Zhao2,3, Xianwen Long2,3, Shu Wang1, Pema-Tenzin Puno2, Jun Deng2.
Abstract
The first copper-catalyzed intermolecular [5+2] homodimerization of hydroxy p-quinone is presented, furnishing bicyclo[3.2.1]octadienone core structures in typically good yields and excellent diastereoselectivities. Applying this synthetic approach enables a concise nine-step total synthesis of (-)-perezoperezone from commercially available 3,5-dimethoxytoluene.Entities:
Keywords: 5+2 cycloaddition; dimerization; natural products; perezoperezone; total synthesis
Year: 2019 PMID： 31608523 DOI： 10.1002/anie.201911978
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336