OBJECTIVE: The findings of resting-state functional MRI studies have suggested that abnormal functional integration between interconnected cortical networks characterises the brain of patients with migraine. The aim of this study was to investigate the functional connectivity between the hypothalamus, brainstem, considered as the migraine generator, and the following areas/networks that are reportedly involved in the pathophysiology of migraine: default mode network (DMN), executive control network, dorsal attention system, and primary and dorsoventral visual networks. METHODS: Twenty patients with chronic migraine (CM) without medication overuse and 20 healthy controls (HCs) were prospectively recruited. All study participants underwent 3-T MRI scans using a 7.5-min resting-state protocol. Using a seed-based approach, we performed a ROI-to-ROI analysis selecting the hypothalamus as the seed. RESULTS: Compared to HCs, patients with CM showed significantly increased neural connectivity between the hypothalamus and brain areas belonging to the DMN and dorsal visual network. We did not detect any connectivity abnormalities between the hypothalamus and the brainstem. The correlation analysis showed that the severity of the migraine headache was positively correlated with the connectivity strength of the hypothalamus and negatively with the connectivity strength of the medial prefrontal cortex, which belongs to the DMN. CONCLUSION: These data provide evidence for hypothalamic involvement in large-scale reorganisation at the functional-network level in CM and in proportion with the perceived severity of the migraine pain.
OBJECTIVE: The findings of resting-state functional MRI studies have suggested that abnormal functional integration between interconnected cortical networks characterises the brain of patients with migraine. The aim of this study was to investigate the functional connectivity between the hypothalamus, brainstem, considered as the migraine generator, and the following areas/networks that are reportedly involved in the pathophysiology of migraine: default mode network (DMN), executive control network, dorsal attention system, and primary and dorsoventral visual networks. METHODS: Twenty patients with chronic migraine (CM) without medication overuse and 20 healthy controls (HCs) were prospectively recruited. All study participants underwent 3-T MRI scans using a 7.5-min resting-state protocol. Using a seed-based approach, we performed a ROI-to-ROI analysis selecting the hypothalamus as the seed. RESULTS: Compared to HCs, patients with CM showed significantly increased neural connectivity between the hypothalamus and brain areas belonging to the DMN and dorsal visual network. We did not detect any connectivity abnormalities between the hypothalamus and the brainstem. The correlation analysis showed that the severity of the migraine headache was positively correlated with the connectivity strength of the hypothalamus and negatively with the connectivity strength of the medial prefrontal cortex, which belongs to the DMN. CONCLUSION: These data provide evidence for hypothalamic involvement in large-scale reorganisation at the functional-network level in CM and in proportion with the perceived severity of the migraine pain.
Authors: Stephan Heinzel; Robert C Lorenz; Quynh-Lam Duong; Michael A Rapp; Lorenz Deserno Journal: Neurobiol Aging Date: 2017-05-10 Impact factor: 4.673
Authors: Yiheng Tu; Minyoung Jung; Randy L Gollub; Vitaly Napadow; Jessica Gerber; Ana Ortiz; Courtney Lang; Ishtiaq Mawla; Wei Shen; Suk-Tak Chan; Ajay D Wasan; Robert R Edwards; Ted J Kaptchuk; Bruce Rosen; Jian Kong Journal: Pain Date: 2019-06 Impact factor: 7.926
Authors: Wei Shen; Yiheng Tu; Randy L Gollub; Ana Ortiz; Vitaly Napadow; Siyi Yu; Georgia Wilson; Joel Park; Courtney Lang; Minyoung Jung; Jessica Gerber; Ishtiaq Mawla; Suk-Tak Chan; Ajay D Wasan; Robert R Edwards; Ted Kaptchuk; Shasha Li; Bruce Rosen; Jian Kong Journal: Neuroimage Clin Date: 2019-03-14 Impact factor: 4.881
Authors: Lars Michels; Nabin Koirala; Franz Riederer; Muthuraman Muthuraman; Sergiu Groppa; Roger Luechinger; Andreas R Gantenbein; Peter S Sandor; Spyros Kollias Journal: J Headache Pain Date: 2021-03-03 Impact factor: 7.277
Authors: Camillo Porcaro; Antonio Di Renzo; Emanuele Tinelli; Giorgio Di Lorenzo; Vincenzo Parisi; Francesca Caramia; Marco Fiorelli; Vittorio Di Piero; Francesco Pierelli; Gianluca Coppola Journal: J Headache Pain Date: 2020-09-14 Impact factor: 7.277