Antigoni Pavlaki1, Nikoleta Printza2, Evangelia Farmaki3, Stella Stabouli2, Anna Taparkou3, Magdalini Sterpi4, John Dotis2, Fotios Papachristou2. 1. Paediatric Nephrology Unit, First Department of Paediatrics, Hippokratio Hospital, Aristotle University of Thessaloniki, 49th Konstantinoupoleos Street, 546 42, Thessaloniki, Greece. antigonipavlaki@yahoo.gr. 2. Paediatric Nephrology Unit, First Department of Paediatrics, Hippokratio Hospital, Aristotle University of Thessaloniki, 49th Konstantinoupoleos Street, 546 42, Thessaloniki, Greece. 3. Paediatric Immunology and Rheumatology Referral Center, First Department of Paediatrics, Hippokratio Hospital, Thessaloniki, Greece. 4. Department of Neonatology and Neonatal Intensive Care Unit, Hippokratio Hospital, Thessaloniki, Greece.
Abstract
BACKGROUND: The ideal management of ureteropelvic junction obstruction (UPJO) remains debatable. This prospective case-control study aimed to investigate if urinary levels of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and serum levels of cystatin C could distinguish surgical from non-surgical cases of UPJO and if they could detect earlier impairment of renal function. METHODS: Biomarkers were measured in the following age-matched groups: (a) 22 infants with surgical UPJO, at initial diagnosis and 12 months postoperatively (groups A1 and A2, respectively); (b) 19 infants with non-surgical UPJO (group B); and (c) 17 controls (group C). Based on serum cystatin C levels, estimated glomerular filtration rate (eGFR) was calculated. RESULTS: Urinary NGAL (uNGAL) was significantly higher in group A1 vs. group A2 (p = 0.02) and in group A1 vs. group C (p = 0.03), whereas there was no statistically significant difference between groups A2 and C (p = 0.77). Likewise, cystatin C levels were significantly higher in group A1 vs. group A2 and in group A1 vs. group C (p = 0.004 and p = 0.02, respectively), but no statistically significant difference between groups A2 and C (p = 0.82). uNGAL and serum cystatin C did not differ between groups B and A, nor did they differ between groups B and C. Cystatin C levels and eGFR of group A1 were significantly higher than those of group A2 and group C (p = 0.0001 and p = 0.02, respectively). CONCLUSION: It seems that NGAL and cystatin C are able to distinguish patients who were treated surgically from healthy controls, and their levels appear to improve significantly following surgery.
BACKGROUND: The ideal management of ureteropelvic junction obstruction (UPJO) remains debatable. This prospective case-control study aimed to investigate if urinary levels of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and serum levels of cystatin C could distinguish surgical from non-surgical cases of UPJO and if they could detect earlier impairment of renal function. METHODS: Biomarkers were measured in the following age-matched groups: (a) 22 infants with surgical UPJO, at initial diagnosis and 12 months postoperatively (groups A1 and A2, respectively); (b) 19 infants with non-surgical UPJO (group B); and (c) 17 controls (group C). Based on serum cystatin C levels, estimated glomerular filtration rate (eGFR) was calculated. RESULTS: Urinary NGAL (uNGAL) was significantly higher in group A1 vs. group A2 (p = 0.02) and in group A1 vs. group C (p = 0.03), whereas there was no statistically significant difference between groups A2 and C (p = 0.77). Likewise, cystatin C levels were significantly higher in group A1 vs. group A2 and in group A1 vs. group C (p = 0.004 and p = 0.02, respectively), but no statistically significant difference between groups A2 and C (p = 0.82). uNGAL and serum cystatin C did not differ between groups B and A, nor did they differ between groups B and C. Cystatin C levels and eGFR of group A1 were significantly higher than those of group A2 and group C (p = 0.0001 and p = 0.02, respectively). CONCLUSION: It seems that NGAL and cystatin C are able to distinguish patients who were treated surgically from healthy controls, and their levels appear to improve significantly following surgery.
Authors: Meghan E Sise; Catherine Forster; Eugenia Singer; David Sola-Del Valle; Barry Hahn; Kai M Schmidt-Ott; Jonathan Barasch; Thomas L Nickolas Journal: Nephrol Dial Transplant Date: 2011-11-01 Impact factor: 5.992
Authors: Jonathan E Heinlen; C Scott Manatt; Brianna C Bright; Bradley P Kropp; Jeffrey B Campbell; Dominic Frimberger Journal: Urology Date: 2008-12-18 Impact factor: 2.649
Authors: Anna Wasilewska; Katarzyna Taranta-Janusz; Wojciech Dębek; Walentyna Zoch-Zwierz; Elżbieta Kuroczycka-Saniutycz Journal: Pediatr Nephrol Date: 2011-01-31 Impact factor: 3.714
Authors: Charan Kumar V Devarakonda; Emily R Shearier; Chaoran Hu; James Grady; Jeremy L Balsbaugh; John H Makari; Fernando A Ferrer; Linda H Shapiro Journal: J Pediatr Urol Date: 2020-06-11 Impact factor: 1.830