Literature DB >> 31606391

Crosstalk of intracellular post-translational modifications in cancer.

Zheng Wu1, Rongting Huang2, Liang Yuan3.   

Abstract

Post-translational modifications (PTMs) have been reported to play pivotal roles in numerous cellular biochemical and physiological processes. Multiple PTMs can influence the actions of each other positively or negatively, termed as PTM crosstalk or PTM code. During recent years, development of identification strategies for PTMs co-occurrence has revealed abundant information of interplay between PTMs. Increasing evidence demonstrates that deregulation of PTMs crosstalk is involved in the genesis and development of various diseases. Insight into the complexity of PTMs crosstalk will help us better understand etiology and provide novel targets for drug therapy. In the present review, we will discuss the important functional roles of PTMs crosstalk in proteins associated with cancer diseases.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cancer-related proteins; Drug target; PTMs crosstalk; Tumorigenesis

Year:  2019        PMID： 31606391     DOI： 10.1016/j.abb.2019.108138

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  16 in total

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Review 4.  Pathological implication of protein post-translational modifications in cancer.

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Authors:  Hongmei Jiang; Yixuan Wang; Jingjing Wang; Yafei Wang; Sheng Wang; Enyang He; Jing Guo; Ying Xie; Jingya Wang; Xin Li; Ziyi Peng; Mengqi Wang; Jian Hou; Zhiqiang Liu
Journal:  Clin Transl Med       Date:  2022-04

9.  Proteome-Wide Identification and Functional Analysis of Lysine Crotonylation in Trichophyton rubrum Conidial and Mycelial Stages.

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Review 10.  Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1.

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Journal:  Front Cell Dev Biol       Date:  2020-03-04
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