Mehmet Akif Camkurt1, İbrahim Fatih Karababa2, Mehmet Emin Erdal3, Sultan Basmacı Kandemir4, Gabriel R Fries5, Hüseyin Bayazıt6, Mustafa Ertan Ay3, Hasan Kandemir7, Özlem Izci Ay3, Salih Coşkun8, Erdinç Çiçek9, Salih Selek5. 1. Department of Psychiatry, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. Electronic address: dr.akif@gmail.com. 2. Department of Psychiatry, Zilan Hospital Batman, Turkey. 3. Department of Medical Biology, Faculty of Medicine, Mersin University, Mersin, Turkey. 4. Manisa Mental Health State Hospital, Manisa, Turkey. 5. Department of Psychiatry, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America. 6. Department of Psychiatry, Texas Tech University Health Science Center at Lubbock, Lubbock, Texas, United States of America. 7. Department of Child and Adolescent Psychiatry, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. 8. Department of Medical Genetics, Faculty of Medicine, Dicle University, Diyarbakır, Turkey. 9. Department of Psychiatry, Çumra State Hospital, Konya, Turkey.
Abstract
BACKGROUND: Bipolar disorder (BPD) is a major psychiatric disorder with an unclear pathophysiology. Peripheral blood samples are easily drawn, making them are good candidates for diagnosing diseases. MicroRNAs are small non-coding RNA transcripts that regulate gene expression by binding to the 3'- UTR of mRNAs and directing their degradation. The aim of this study was to use blood plasma to investigate microRNA dysregulations in bipolar manic and euthymic patients. SUBJECTS AND METHODS: Blood samples were collected from 58 patients with bipolar I disorder (19 manic, 39 euthymic) and 51 healthy controls. RESULTS: Four microRNAs (miR-29a-3p, p = 0.035; miR-106b-5p, p = 0.014; miR-107, p = 0.011; and miR-125a-3p, p = 0.014) were upregulated in the entire bipolar group, compared to the healthy controls. Seven microRNAs (miR-9-5p, p = 0.032; miR-29a-3p, p = 0.001; miR-106a-5p, p = 0.034; miR-106b-5p, p = 0.003; miR-107, p < 0.001; miR-125a-3p, p = 0.016; and miR-125b-5p, p = 0.004) were more upregulated in bipolar manic patients compared to the healthy controls, and two microRNAs (miR-106a-5p, p = 0.013, and miR-107, p = 0.021) showed statistically significant upregulation in the manic patients compared to the euthymic patients. CONCLUSIONS: Our results showed greater miRNA dysregulation in the manic patients than in the euthymic patients. Two microRNAs could be more selective for bipolar manic episodes. Future studies should include depressive patients along with euthymic and manic patients.
BACKGROUND:Bipolar disorder (BPD) is a major psychiatric disorder with an unclear pathophysiology. Peripheral blood samples are easily drawn, making them are good candidates for diagnosing diseases. MicroRNAs are small non-coding RNA transcripts that regulate gene expression by binding to the 3'- UTR of mRNAs and directing their degradation. The aim of this study was to use blood plasma to investigate microRNA dysregulations in bipolar manic and euthymic patients. SUBJECTS AND METHODS: Blood samples were collected from 58 patients with bipolar I disorder (19 manic, 39 euthymic) and 51 healthy controls. RESULTS: Four microRNAs (miR-29a-3p, p = 0.035; miR-106b-5p, p = 0.014; miR-107, p = 0.011; and miR-125a-3p, p = 0.014) were upregulated in the entire bipolar group, compared to the healthy controls. Seven microRNAs (miR-9-5p, p = 0.032; miR-29a-3p, p = 0.001; miR-106a-5p, p = 0.034; miR-106b-5p, p = 0.003; miR-107, p < 0.001; miR-125a-3p, p = 0.016; and miR-125b-5p, p = 0.004) were more upregulated in bipolar manicpatients compared to the healthy controls, and two microRNAs (miR-106a-5p, p = 0.013, and miR-107, p = 0.021) showed statistically significant upregulation in the manicpatients compared to the euthymic patients. CONCLUSIONS: Our results showed greater miRNA dysregulation in the manicpatients than in the euthymic patients. Two microRNAs could be more selective for bipolar manic episodes. Future studies should include depressivepatients along with euthymic and manicpatients.
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