| Literature DB >> 31605568 |
Bhupal S Karki1,2, Lalita Devi1,2, Ayushi Pokhriyal1, Ruchir Kant3, Namrata Rastogi1,2.
Abstract
A metal-free, regioselective synthesis of trisubstituted pyrroles has been developed through a formal [3+2] cycloaddition reaction between 2H-azirines and nitroalkenes under visible light/photoredox-catalyzed conditions. The reaction proceeds through 2H-azaallenyl radical addition on β-nitrostyrenes in a Michael fashion followed by a base-mediated denitration reaction. The directive group influence of the nitro group controls the regiochemistry of the reaction.Entities:
Keywords: 2H-azirines; [3+2] cycloaddition; nitroalkenes; trisubstituted pyrroles; visible light reaction
Year: 2019 PMID： 31605568 DOI： 10.1002/asia.201901068
Source DB: PubMed Journal: Chem Asian J ISSN： 1861-471X