Yoon Jin Choi1, Dong Wook Shin2, Wooyoung Jang3, Dong Ho Lee1, Su-Min Jeong4, Sanghyun Park5, Kyung-do Han5, Yong Gyu Park6. 1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. 2. Department of Family Medicine and Supportive Care Center, Samsung Comprehensive Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. dwshin.md@gmail.com. 3. Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea. 4. Department of Family Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea. 5. Department of Biostatistics, The Catholic University of Korea, Seoul, Republic of Korea. 6. Department of Biostatistics, The Catholic University of Korea, Seoul, Republic of Korea. ygpark@catholic.ac.kr.
Abstract
PURPOSE: This study was designed to compare the risk of dementia, including Alzheimer's disease (AD) and vascular dementia (VaD), between gastric cancer patients who underwent gastrectomy and the general population. METHODS: All patients (n = 63,998) aged ≥ 50 years who received a diagnosis of gastric cancer and underwent curative gastrectomy between 2007 and 2012 and a noncancer control population (n = 203,276), matched by age and sex, were identified from the Korean National Health Insurance Services and traced until 2017. Hazard ratios and 95% confidence intervals for dementia were calculated with a Cox regression analysis. RESULTS: Gastric cancer patients who received a gastrectomy showed an increased risk of AD [adjusted hazard ration (aHR) 1.08, 95% confidence interval (CI) 1.03-1.14], and the risk was especially marked for those who received a total gastrectomy (aHR 1.39, 95% CI 1.25-1.54). Gastric cancer survivors showed a decreased risk for VaD (aHR 0.85; 95% CI 0.73-0.98) regardless of operation type. Those who received continual vitamin B12 supplementation after a total gastrectomy were less likely than controls to develop AD (aHR 0.71; 95% CI 0.54-0.92). CONCLUSIONS: Compared with controls, gastric cancer patients who received a total gastrectomy had an increased incidence of AD and a decreased risk of VaD. Our results suggest that vitamin B12 deficiency might play a role in the development of AD and highlight the need for vitamin B12 supplementation after total gastrectomy.
PURPOSE: This study was designed to compare the risk of dementia, including Alzheimer's disease (AD) and vascular dementia (VaD), between gastric cancerpatients who underwent gastrectomy and the general population. METHODS: All patients (n = 63,998) aged ≥ 50 years who received a diagnosis of gastric cancer and underwent curative gastrectomy between 2007 and 2012 and a noncancer control population (n = 203,276), matched by age and sex, were identified from the Korean National Health Insurance Services and traced until 2017. Hazard ratios and 95% confidence intervals for dementia were calculated with a Cox regression analysis. RESULTS:Gastric cancerpatients who received a gastrectomy showed an increased risk of AD [adjusted hazard ration (aHR) 1.08, 95% confidence interval (CI) 1.03-1.14], and the risk was especially marked for those who received a total gastrectomy (aHR 1.39, 95% CI 1.25-1.54). Gastric cancer survivors showed a decreased risk for VaD (aHR 0.85; 95% CI 0.73-0.98) regardless of operation type. Those who received continual vitamin B12 supplementation after a total gastrectomy were less likely than controls to develop AD (aHR 0.71; 95% CI 0.54-0.92). CONCLUSIONS: Compared with controls, gastric cancerpatients who received a total gastrectomy had an increased incidence of AD and a decreased risk of VaD. Our results suggest that vitamin B12 deficiency might play a role in the development of AD and highlight the need for vitamin B12 supplementation after total gastrectomy.
Authors: Bo Ri Kim; Dong Ho Lee; Hyun Ik Shim; Jee Woo Kim; Sanghyun Park; Cheol Min Shin; Kyungdo Han; Sang Woong Youn Journal: Ann Dermatol Date: 2022-05-20 Impact factor: 0.722
Authors: Anna Andrea Lauer; Heike Sabine Grimm; Birgit Apel; Nataliya Golobrodska; Lara Kruse; Elina Ratanski; Noemi Schulten; Laura Schwarze; Thomas Slawik; Saskia Sperlich; Antonia Vohla; Marcus Otto Walter Grimm Journal: Biomolecules Date: 2022-01-14