Gunn Ammitzbøll1,2, Kenneth Geving Andersen3,4, Pernille Envold Bidstrup5, Christoffer Johansen6,7, Charlotte Lanng8, Niels Kroman8,9, Bo Zerahn10, Ole Hyldegaard11,12, Elisabeth Wreford Andersen13, Susanne Oksbjerg Dalton6,14. 1. Survivorship and Inequality in Cancer, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark. gunnam@cancer.dk. 2. Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Næstved, Denmark. gunnam@cancer.dk. 3. Department of Anaesthesiology and Intensive Care, Zealand University Hospital, Køge, Denmark. 4. Section for Surgical Pathophysiology, Rigshospitalet, Copenhagen, Denmark. 5. Psychosocial Aspects in Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark. 6. Survivorship and Inequality in Cancer, Danish Cancer Society Research Center, Strandboulevarden 49, 2100, Copenhagen, Denmark. 7. CASTLE Late Effects Unit, Department of Oncology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 8. Department of Breast Surgery, Copenhagen University Hospital Herlev/Rigshospitalet, Copenhagen, Denmark. 9. Danish Cancer Society, Copenhagen, Denmark. 10. Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Herlev, Copenhagen, Denmark. 11. Section for Hyperbaric Oxygen Treatment, Department for Anaesthetics and Operations, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 12. Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 13. Unit of Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark. 14. Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Næstved, Denmark.
Abstract
PURPOSE: Persistent pain is a known challenge among breast cancer survivors. In secondary analyses of a randomized controlled trial, we examined the effect of progressive resistance training on persistent pain in the post-operative year in women treated for breast cancer with axillary lymph node dissection. METHODS: We randomized 158 women after BC surgery with Axillary Lymph Node Dissection (ALND) (1:1) tousual care or a 1-year, supervised and self-administered, progressive resistance training intervention initiated 3 weeks after surgery. A questionnaire at baseline, 20 weeks and 12 months assessed the intensity and frequency of pain, neuropathic pain and influence of pain on aspects of daily life. We analysed the effect using linear mixed models and multinomial logistic regression models for repeated measures. RESULTS: A high percentage of participants experienced baseline pain (85% and 83% in the control and intervention groups respectively) and by the 12 month assessment these numbers were more than halved. A high proportion of participants also experienced neuropathic pain (88% and 89% in control and intervention group respectively), a finding that was stable throughout the study period. The effect on intensity of pain indicators favoured the exercise group, although most estimates did not reach statistical significance, with differences being small. CONCLUSION:For women who had BC surgery withALND, our progressive resistance training intervention conferred no benefit over usual care in reducing pain. Importantly, it did not increase the risk of pain both in the short and long term rehabilitative phase.
RCT Entities:
PURPOSE: Persistent pain is a known challenge among breast cancer survivors. In secondary analyses of a randomized controlled trial, we examined the effect of progressive resistance training on persistent pain in the post-operative year in women treated for breast cancer with axillary lymph node dissection. METHODS: We randomized 158 women after BC surgery with Axillary Lymph Node Dissection (ALND) (1:1) to usual care or a 1-year, supervised and self-administered, progressive resistance training intervention initiated 3 weeks after surgery. A questionnaire at baseline, 20 weeks and 12 months assessed the intensity and frequency of pain, neuropathic pain and influence of pain on aspects of daily life. We analysed the effect using linear mixed models and multinomial logistic regression models for repeated measures. RESULTS: A high percentage of participants experienced baseline pain (85% and 83% in the control and intervention groups respectively) and by the 12 month assessment these numbers were more than halved. A high proportion of participants also experienced neuropathic pain (88% and 89% in control and intervention group respectively), a finding that was stable throughout the study period. The effect on intensity of pain indicators favoured the exercise group, although most estimates did not reach statistical significance, with differences being small. CONCLUSION: For women who had BC surgery with ALND, our progressive resistance training intervention conferred no benefit over usual care in reducing pain. Importantly, it did not increase the risk of pain both in the short and long term rehabilitative phase.
Entities:
Keywords:
Axillary lymph node dissection; Breast cancer; Oncology; Pain; Resistance training
Authors: Kristin L Schreiber; Nantthansorn Zinboonyahgoon; K Mikayla Flowers; Valerie Hruschak; Kara G Fields; Megan E Patton; Emily Schwartz; Desiree Azizoddin; Mieke Soens; Tari King; Ann Partridge; Andrea Pusic; Mehra Golshan; Rob R Edwards Journal: Ann Surg Oncol Date: 2021-01-15 Impact factor: 5.344
Authors: Priya Kannan; Hiu Ying Lam; Tsz Kiu Ma; Chiu Ngai Lo; Ting Yan Mui; Wing Yan Tang Journal: Qual Life Res Date: 2021-06-29 Impact factor: 4.147