Literature DB >> 31604528

A novel long noncoding RNA HHIP-AS1 suppresses hepatocellular carcinoma progression through stabilizing HHIP mRNA.

Changwen Bo1, Xiuli Li1, Li He1, Sujing Zhang1, Na Li2, Yonghui An3.   

Abstract

Aberrant expression of long non-coding RNAs (lncRNAs) has been observed in hepatocellular carcinoma (HCC) and confirmed to participate in the initiation and progression of HCC. In the present study, we identified a novel functional lncRNA, hedgehog-interacting protein antisense RNA 1 (HHIP-AS1). The expression levels of HHIP-AS1 were significantly decreased in HCC tissues. Downregulation of HHIP-AS1 expression correlated with larger tumor size, metastasis, and advanced TNM stage, and also predicted worse overall survival rate of HCC patients. Through performing overexpression and knockdown experiments, the biological function of HHIP-AS1 was identified to suppress HCC cell proliferation, migration and invasion, while promote apoptosis. Further investigation showed that HHIP-AS1 interacted with and positively regulated the stability of HHIP mRNA in a HuR-dependent manner. HHIP-AS1 exerted its suppressive effects through HHIP. Taken together, our findings demonstrate that HHIP-AS1 represses HCC progression by promoting HHIP expression, and indicate that the use of HHIP-AS1 may offer a promising treatment for HCC patients.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Antisense RNA; Degradation; HHIP; HuR; Stability

Year:  2019        PMID： 31604528     DOI： 10.1016/j.bbrc.2019.09.137

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.

Authors:  Jasmin Bartl; Marco Zanini; Flavia Bernardi; Antoine Forget; Lena Blümel; Julie Talbot; Daniel Picard; Nan Qin; Gabriele Cancila; Qingsong Gao; Soumav Nath; Idriss Mahoungou Koumba; Marietta Wolter; François Kuonen; Maike Langini; Thomas Beez; Christopher Munoz; David Pauck; Viktoria Marquardt; Hua Yu; Judith Souphron; Mascha Korsch; Christina Mölders; Daniel Berger; Sarah Göbbels; Frauke-Dorothee Meyer; Björn Scheffler; Barak Rotblat; Sven Diederichs; Vijay Ramaswamy; Hiromishi Suzuki; Anthony Oro; Kai Stühler; Anja Stefanski; Ute Fischer; Gabriel Leprivier; Dieter Willbold; Gerhard Steger; Alexander Buell; Marcel Kool; Peter Lichter; Stefan M Pfister; Paul A Northcott; Michael D Taylor; Arndt Borkhardt; Guido Reifenberger; Olivier Ayrault; Marc Remke
Journal:  Nat Commun       Date:  2022-07-13       Impact factor: 17.694

2.  The Long Non-Coding RNA IDH1-AS1 Promotes Prostate Cancer Progression by Enhancing IDH1 Enzyme Activity.

Authors:  Shuo Wu; Liucheng Ding; Hewei Xu; Jie Gao; Yunpeng Shao; Sicong Zhang; Zhongqing Wei
Journal:  Onco Targets Ther       Date:  2020-08-07       Impact factor: 4.147

3.  Long Noncoding RNA SCIRT Promotes HUVEC Angiogenesis via Stabilizing VEGFA mRNA Induced by Hypoxia.

Authors:  Lianze Gao; Jihong Yang; Yi Li; Keyu Liu; Huilin Sun; Jing Tang; Zhengyuan Xia; Liangqing Zhang; Zhe Hu
Journal:  Oxid Med Cell Longev       Date:  2022-06-03       Impact factor: 7.310

Review 4.  Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives.

Authors:  Jia Song; Yuexin Ge; Xiaoyu Sun; Qiutong Guan; Shiqiang Gong; Minjie Wei; Jumin Niu; Lin Zhao
Journal:  Mol Cancer       Date:  2022-05-17       Impact factor: 41.444

5.  HHIP Overexpression Suppresses Human Gastric Cancer Progression and Metastasis by Reducing Its CpG Island Methylation.

Authors:  Yu Song; Jianchen Tu; Yanan Cheng; Fang Zhou; Peilin Liu; Shuangshuang Zhou; Yongjun Gu; Yang Sun
Journal:  Front Oncol       Date:  2020-12-22       Impact factor: 6.244

Review 6.  The Impact of Long Non-Coding RNAs in the Pathogenesis of Hepatocellular Carcinoma.

Authors:  Soudeh Ghafouri-Fard; Mahdi Gholipour; Bashdar Mahmud Hussen; Mohammad Taheri
Journal:  Front Oncol       Date:  2021-04-21       Impact factor: 6.244

7.  Long non‑coding RNA HHIP‑AS1 inhibits lung cancer epithelial‑mesenchymal transition and stemness by regulating PCDHGA9.

Authors:  Zhuanzhuan Zhou; Yanping Lai; Shan Cao; Qifang Zhuo; Huiqin Tang
Journal:  Mol Med Rep       Date:  2021-10-13       Impact factor: 2.952

8.  Long Noncoding RNA DIO3OS Hinders Cell Malignant Behaviors of Hepatocellular Carcinoma Cells Through the microRNA-328/Hhip Axis.

Authors:  Zhanpeng Wang; Lina Song; Yanshuo Ye; Wei Li
Journal:  Cancer Manag Res       Date:  2020-05-25       Impact factor: 3.989

9.  Long noncoding RNA MYLK-AS1 promotes growth and invasion of hepatocellular carcinoma through the EGFR/HER2-ERK1/2 signaling pathway.

Authors:  Juan Liu; Si-Yuan Zhao; Qiwei Jiang; Yuanyuan Qu; Xiaomei Huang; Jundong Du; Wanjun Sun; Qinong Ye
Journal:  Int J Biol Sci       Date:  2020-04-27       Impact factor: 6.580

Review 10.  mRNA Post-Transcriptional Regulation by AU-Rich Element-Binding Proteins in Liver Inflammation and Cancer.

Authors:  Dobrochna Dolicka; Cyril Sobolewski; Marta Correia de Sousa; Monika Gjorgjieva; Michelangelo Foti
Journal:  Int J Mol Sci       Date:  2020-09-11       Impact factor: 5.923
  10 in total

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