OBJECTIVE: To elucidate the protective effect of berberine on olanzapine induced-metabolic syndrome. METHODS: This prospective experimental study involved thirty Sprague-Dawley male rats which were divided into three groups. Group A (n=10): Rats treated with distilled water, Group B (n=10): Rats treated with olanzapine, Group C (n=10): Rats treated with olanzapine plus berberine. The duration of the study was 8 weeks, baseline and follow up data were evaluated. Fasting blood glucose(FBG) total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL), Low density lipoprotein (LDL), atherogenic index of plasma (AI), fasting serum insulin level, insulin resistance, β- cell function and insulin sensitivity were evaluated.SPSS 20. RESULTS: Olanzepine led to significant deterioration in gluco-metabolic profile compared with control P<0.01. Olanzapine plus berberine improved body weight, FBG, FSI, HOMA-IR and QUICKI compared with olanzapine P=0.0001. CONCLUSIONS: Berberine attenuates olanzapine induced-metabolic via amelioration of gluco-lipid disturbances.
OBJECTIVE: To elucidate the protective effect of berberine on olanzapine induced-metabolic syndrome. METHODS: This prospective experimental study involved thirty Sprague-Dawley male rats which were divided into three groups. Group A (n=10): Rats treated with distilled water, Group B (n=10): Rats treated with olanzapine, Group C (n=10): Rats treated with olanzapine plus berberine. The duration of the study was 8 weeks, baseline and follow up data were evaluated. Fasting blood glucose(FBG) total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL), Low density lipoprotein (LDL), atherogenic index of plasma (AI), fasting serum insulin level, insulin resistance, β- cell function and insulin sensitivity were evaluated.SPSS 20. RESULTS: Olanzepine led to significant deterioration in gluco-metabolic profile compared with control P<0.01. Olanzapine plus berberine improved body weight, FBG, FSI, HOMA-IR and QUICKI compared with olanzapine P=0.0001. CONCLUSIONS: Berberine attenuates olanzapine induced-metabolic via amelioration of gluco-lipid disturbances.
Authors: Gaber El-Saber Batiha; Hayder M Al-Kuraishy; Thabat J Al-Maiahy; Ali K Al-Buhadily; Hebatallah M Saad; Ali I Al-Gareeb; Jesus Simal-Gandara Journal: Diabetol Metab Syndr Date: 2022-09-08 Impact factor: 5.395