Literature DB >> 3160311

Isolation of an acidic polysaccharide antigen from Propionibacterium acnes.

O J Iversen, A B Dalen, H B Svindland.   

Abstract

An acidic polysaccharide antigen is released from Propionibacterium acnes I and II during growth. The molecular weight of the antigen was heterogeneous and when fractionated on a Sepharose CL-6B column, the antigen was detected at Kav values of between 0.1 and 1.0. The pI of the antigen was below 3.5. Rabbit antiserum raised against purified acidic-polysaccharide agglutinated P. acnes showing that the polysaccharide was a surface antigen. Human antibodies towards whole P. acnes-II organisms were quantitated by an agglutination technique, and antibodies towards purified acidic polysaccharide were quantitated by single radial immunodiffusion. A high prevalence of antibodies against whole bacteria and the acidic polysaccharide was found in sera from healthy individuals. The antibody titre in sera from acne patients was significantly higher than that in sera from blood donors.

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Year:  1985        PMID： 3160311     DOI： 10.1007/bf00404321

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  12 in total

1.  STUDY OF ANTIBODY LEVELS TO CORYNEBACTERIUM ACNES. IN THE SERUM OF PATIENTS WITH ACNE VULGARIS, USING BACTERIAL AGGLUTINATION, AGAR GEL IMMUNODIFFUSION, AND IMMUNOFLUORESCENCE TECHNIQUES.

Authors:  S M PUHVEL; M BARFATANI; M WARNICK; T H STERNBERG
Journal:  Arch Dermatol       Date:  1964-10

2.  A comparative study of anaerobic Coryneforms. Attempts to correlate their anti-tumour activity with their serological properties and ability to stimulate the lymphoreticular system.

Authors:  W H McBride; J Dawes; N Dunbar; A Ghaffar; M F Woodruff
Journal:  Immunology       Date:  1975-01       Impact factor: 7.397

3.  Properties of an antigenic polysaccharide from Corynebacterium parvum.

Authors:  J Dawes; S J Tuach; W H McBride
Journal:  J Bacteriol       Date:  1974-10       Impact factor: 3.490

4.  Determination of molecular weight of acid mucopolysaccharides by gel electrophoresis.

Authors:  M B Mathews; L Decker
Journal:  Biochim Biophys Acta       Date:  1971-07-20

5.  Corynebacterium parvum: a synonym for Propionibacterium acnes?

Authors:  C S Cummins; J L Johnson
Journal:  J Gen Microbiol       Date:  1974-02

6.  Thermostable Neisseria gonorrhoeae antigens examined by a bacterial agglutination test.

Authors:  G E Angelsen; J Maeland
Journal:  Acta Pathol Microbiol Scand C       Date:  1977-08

7.  Differentiation of two groups of Corynebacterium acnes.

Authors:  J G Voss
Journal:  J Bacteriol       Date:  1970-02       Impact factor: 3.490

8.  Cell wall composition and deoxyribonucleic acid similarities among the anaerobic coryneforms, classical propionibacteria, and strains of Arachnia propionica.

Authors:  J L Johnson; C S Cummins
Journal:  J Bacteriol       Date:  1972-03       Impact factor: 3.490

9.  The effect of acidic polysaccharides and prostaglandin-like substances isolated from Propionibacterium acnes on granulocyte chemotaxis.

Authors:  J Belsheim; A Dalen; H Gnarpe; L Hellgren; O J Iversen; J Vincent
Journal:  Experientia       Date:  1979-12-15

10.  Corynebacterium acnes. Presence of complement fixing antibodies to corynebacterium acnes in the sera of patients with acne vulgaris.

Authors:  S M Puhvel; I K Hoffman; T H Sternberg
Journal:  Arch Dermatol       Date:  1966-03
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  1 in total

1.  Antibodies elicited by inactivated propionibacterium acnes-based vaccines exert protective immunity and attenuate the IL-8 production in human sebocytes: relevance to therapy for acne vulgaris.

Authors:  Teruaki Nakatsuji; Yu-Tsueng Liu; Cheng-Po Huang; Christos C Zoubouis; Richard L Gallo; Chun-Ming Huang
Journal:  J Invest Dermatol       Date:  2008-05-08       Impact factor: 8.551
  1 in total

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