| Literature DB >> 31603017 |
Yanfang Ding1, Yingying Ding2, Yutong Wang2, Changyuan Wang2, Meng Gao2, Youwei Xu2, Xiaodong Ma2, Jianping Wu2, Lei Li2,3.
Abstract
In this study, mixed micelles of Soluplus® and TPGS were developed for co-administering docetaxel (DTX) and piperine (PIP) for exerting the synergistic effect, which increased the cytotoxicity and improved the anti-cancer activity in HepG2 cell lines compared to free DTX. These in vitro (MTT assay, intracellular uptake of micelles) and in vivo (pharmacokinetic study, immunostaining, TUNEL analysis) studies exhibited the advantages of co-delivery of anticancer drugs with Soluplus®/TPGS by mixed micelles and furthermore established that co-delivery of DTX and PIP via the mixed micelles of Soluplus®/TPGS could be a promising strategy for the treatment of liver cancer.Entities:
Keywords: Co-delivery; cancer therapy; docetaxel; mixed micelles; piperine
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Year: 2019 PMID： 31603017 DOI： 10.1080/10837450.2019.1679834
Source DB: PubMed Journal: Pharm Dev Technol ISSN： 1083-7450 Impact factor: 3.133