| Literature DB >> 31602247 |
Jiancheng Xi1, Xiaobo Luo1, Yipeng Wang1, Jinglong Li1, Lixin Guo1, Guangseng Wu1, Qingui Li1.
Abstract
It has been reported that tetrahydrocurcumin has hypoglycemic, hypolipidemic, anti-metastasis, anticancer and anti-depressant pharmacological effects, and its antioxidative, hypoglycemic and hypolipidemic properties are better than those of curcumin. The present study assessed whether tetrahydrocurcumin exerts a neuroprotective effect against spinal cord injury (SCI) and investigated the underlying mechanisms. In a rat model of SCI, tetrahydrocurcumin enhanced the average Basso-Beattie-Bresnahan scores, inhibited water accumulation in the spinal cord and decreased inflammatory factors. Furthermore, oxidative stress and apoptosis (caspase-3 activity and B-cell lymphoma 2-associated X protein levels) were also suppressed in SCI rats treated with tetrahydrocurcumin. Tetrahydrocurcumin effectively decreased the gene expression of matrix metalloproteinase-3 and -13, as well as cyclooxygenase-2, promoted the phosphorylation of Akt and enhanced the protein expression of forkhead box (FOX)O4 in SCI rats. The present study delineates that tetrahydrocurcumin protects against SCI and inhibits the oxidative stress response by regulating the FOXO4 in SCI model rats.Entities:
Keywords: forkhead box O; oxidative stress; spinal cord injury; tetrahydrocurcumin
Year: 2019 PMID： 31602247 PMCID： PMC6777287 DOI： 10.3892/etm.2019.7974
Source DB: PubMed Journal: Exp Ther Med ISSN： 1792-0981 Impact factor: 2.447