INTRODUCTION: Prostate cancer (PCa) patients who are classified into the intermediate risk category represent a heterogeneous population needing further preoperative risk assessment. OBJECTIVES: To evaluate clinical total testosterone (TT) associations with lymph node invasion (LNI) in intermediate risk PCa. MATERIAL AND METHODS: Between November 2014 and July 2016, intermediate risk PCa was assessed in 154 patients who underwent extended pelvic lymph node dissection if the risk of LNI was higher than 5%. Clinical factors associated with the risk LNI were investigated by the multinomial logistic regression model. RESULTS: The risk of LNI was assessed higher than 5% in 40.9% of cases of whom 15.5% had LNI. In the multivariate model, the risk of LNI was independently increased by prostate specific antigen (OR = 1.185; p = 0.021) and TT (OR = 1.004; p = 0.036). As a result, TT was an independent factor that associated with LNI because it increased the risk of LNI by 4% for each increment unit of TT. CONCLUSION: Preoperative TT independently increased the risk of LNI in the intermediate risk class of PCa patients elected to radical prostatectomy and extended pelvic lymph node dissection. TT might be a useful preoperative factor for stratifying intermediate risk patients because of the positive association of TT with high grade tumors.
INTRODUCTION: Prostate cancer (PCa) patients who are classified into the intermediate risk category represent a heterogeneous population needing further preoperative risk assessment. OBJECTIVES: To evaluate clinical total testosterone (TT) associations with lymph node invasion (LNI) in intermediate risk PCa. MATERIAL AND METHODS: Between November 2014 and July 2016, intermediate risk PCa was assessed in 154 patients who underwent extended pelvic lymph node dissection if the risk of LNI was higher than 5%. Clinical factors associated with the risk LNI were investigated by the multinomial logistic regression model. RESULTS: The risk of LNI was assessed higher than 5% in 40.9% of cases of whom 15.5% had LNI. In the multivariate model, the risk of LNI was independently increased by prostate specific antigen (OR = 1.185; p = 0.021) and TT (OR = 1.004; p = 0.036). As a result, TT was an independent factor that associated with LNI because it increased the risk of LNI by 4% for each increment unit of TT. CONCLUSION: Preoperative TT independently increased the risk of LNI in the intermediate risk class of PCa patients elected to radical prostatectomy and extended pelvic lymph node dissection. TT might be a useful preoperative factor for stratifying intermediate risk patients because of the positive association of TT with high grade tumors.
Authors: Paolo Capogrosso; Eugenio Ventimiglia; Marco Moschini; Luca Boeri; Elena Farina; Nadia Finocchio; Giorgio Gandaglia; Nicola Fossati; Alberto Briganti; Franscesco Montorsi; Andrea Salonia Journal: Prostate Date: 2016-10-24 Impact factor: 4.104
Authors: Lisa Moris; Thomas Van den Broeck; Lorenzo Tosco; Anthony Van Baelen; Paolo Gontero; Robert Jeffrey Karnes; Wouter Everaerts; Maarten Albersen; Patrick J Bastian; Piotr Chlosta; Frank Claessens; Felix K Chun; Markus Graefen; Christian Gratzke; Burkhard Kneitz; Giansilvio Marchioro; Rafael Sanchez Salas; Bertrand Tombal; Henk Van Der Poel; Jochen Christoph Walz; Gert De Meerleer; Alberto Bossi; Karin Haustermans; Francesco Montorsi; Hendrik Van Poppel; Martin Spahn; Alberto Briganti; Steven Joniau Journal: Front Surg Date: 2016-12-16