| Literature DB >> 31601998 |
Diana Corallo1, Michael Donadon2, Marcella Pantile2, Viktoryia Sidarovich3, Simona Cocchi3, Michela Ori4, Miriam De Sarlo4, Simona Candiani5, Chiara Frasson6, Martin Distel7, Alessandro Quattrone3, Carlo Zanon6, Giuseppe Basso8, Gian Paolo Tonini2, Sanja Aveic9,10.
Abstract
The RNA-binding protein LIN28B regulates developmental timing and determines stem cell identity by suppressing the let-7 family of microRNAs. Postembryonic reactivation of LIN28B impairs cell commitment to differentiation, prompting their transformation. In this study, we assessed the extent to which ectopic lin28b expression modulates the physiological behavior of neural crest cells (NCC) and governs their transformation in the trunk region of developing embryos. We provide evidence that the overexpression of lin28b inhibits sympathoadrenal cell differentiation and accelerates NCC migration in two vertebrate models, Xenopus leavis and Danio rerio. Our results highlight the relevance of ITGA5 and ITGA6 in the LIN28B-dependent regulation of the invasive motility of tumor cells. The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms.Entities:
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Year: 2019 PMID： 31601998 PMCID： PMC7206034 DOI： 10.1038/s41418-019-0425-3
Source DB: PubMed Journal: Cell Death Differ ISSN： 1350-9047 Impact factor: 15.828