| Literature DB >> 31601980 |
Kai Yamamoto1,2, Yushi Futamura1, Rachael A Uson-Lopez1, Harumi Aono1, Takeshi Shimizu1, Hiroyuki Osada3,4.
Abstract
A new antifungal compound YO-001A was found from the culture broth of Streptomyces sp. YO15-A001, which was isolated from a soil sample collected in Toyama Prefecture. YO-001A was identified through morphological changes-based screening of the rice blast fungus, Pyricularia oryzae (P. oryzae). YO-001A is a new 26-membered macrolide of the oligomycin family, which exhibits potent antifungal activity against P. oryzae with an IC50 of 0.012 µM by disrupting mitochondrial respiration via inhibition of the FOF1-ATPase activity.Entities:
Mesh：
Substances：
Year: 2019 PMID： 31601980 DOI： 10.1038/s41429-019-0239-z
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649